Red ginseng extract protects against aflatoxin B1 and fumonisins-induced hepatic pre-cancerous lesions in rats
Red ginseng extract protects against aflatoxin B1 and fumonisins-induced hepatic pre-cancerous lesions in rats
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DOI：
10.1016/j.fct.2009.12.006
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发表时间：
2010-02-01
影响因子：
4.3
通讯作者：
Mannaa, Fathia A.
中科院分区：
文献类型：
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作者：
Abdel-Wahhab, Mosaad A.;Hassan, Nabila S.;Mannaa, Fathia A.
本研究旨在评价人参提取物对黄曲霉毒素B-1(AFB(1))和伏马菌素(FB)处理的雌性SD大鼠癌前病变的化学预防作用。6个试验组共治疗12周，包括对照组、GE单独治疗组(150 mg/kgbw)、前2周口服黄曲霉毒素(1)组(17 mg/kg bw)和第6~8周口服FB污染饲料(250 mg/kg饲料)组：真菌毒素方案期间给予GE至第10周；在AFB(1)给药前2周一直服用GE至FB治疗结束；霉菌毒素序贯处理可引起大鼠血清生化指标的显著变化，并伴有肝组织的严重组织学和组织化学改变。在真菌毒素治疗期间、之前或之后给予GE治疗可改善肝脏的所有生化参数和组织学图像。更有甚者。在给予真菌毒素后使用GE治疗被发现更有效。说明锗具有癌前病变的保护作用和治疗作用。(C)2009爱思唯尔有限公司。保留所有权利。
The current Study was conducted to evaluate the chemoprevention effects of ginseng extract (GE) against pre-cancerous lesions in female Sprague-Dawley rats treated with aflatoxin B-1 (AFB(1)) and fumonisin (FB). Six experimental groups treated for 12 weeks and included: the control group, the GE alone-treated group (150 mg/kg b w), the group treated orally with AFB(1) (17 mu g/kg b w) during the first 2 weeks and fed FB-contaminated diet (250 mg/kg diet) during the 6th to 8th weeks: the group treated with GE during the mycotoxin protocol and continued till week 10; the group treated with GE 2 weeks before AFB(1) administration and continued till the end of FB treatment and the group treated with GE for 4 weeks after the toxin protocol stopped. The sequential mycotoxins treatment induced significant changes in serum biochemical parameters accompanied by severe histological and histochemical changes of the liver tissue. Treatment with GE during, before or after the treatment with the mycotoxins improved all biochemical parameters and histological picture of the liver. Moreover. treatment with GE after the administration of the mycotoxins was found to be more effective. it could be concluded that GE has a protective effects as pre-cancerous lesions and therapeutic effects as well. (C) 2009 Elsevier Ltd. All rights reserved.