Cerebral Microbleeds and Cognition The Epidemiology of Dementia in Singapore Study
Cerebral Microbleeds and Cognition The Epidemiology of Dementia in Singapore Study
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DOI：
10.1097/wad.0000000000000015
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发表时间：
2014-04-01
影响因子：
2.1
通讯作者：
Venketasubramanian, Narayanaswamy
中科院分区：
文献类型：
--
作者：
Hilal, Saima;Saini, Monica;Venketasubramanian, Narayanaswamy
脑微出血（CMB）被认为是脑小血管疾病的新标志物。然而，与认知障碍的联系仍不清楚。我们调查了CMBs是否独立于其他传统的脑小血管疾病标志物与认知有关。来自基于人群的新加坡中国眼科研究的中国受试者，未通过初始认知筛查，并被招募到正在进行的新加坡痴呆症流行病学研究中，接受神经心理学测试和3 T脑磁共振成像。使用脑观察者微出血量表在磁共振成像上对CMB的存在和数量进行分级。其他分级的磁共振成像病变包括存在腔隙、白色病变和总脑体积。管理一个全面的神经心理电池和认知功能总结为复合和特定领域的Z分数。在282例受试者中，91例（32.3%）有任何CMB，其中36例（12.8%）有多个CMB。CMB独立于心血管危险因素和其他脑小血管疾病标志物，与综合Z评分（每次CMB增加的平均差异：-0.06; 95%置信区间：-0.11，-0.01）和特定领域Z评分（包括执行功能、注意力和视觉结构）反映的认知功能较差显著相关。在中国受试者中，CMB独立于脑小血管疾病的其他伴随标志物，与认知功能较差相关。
Cerebral microbleeds (CMBs) are considered to be a novel marker of cerebral small vessel disease. However, the link with cognitive impairment remains unclear. We investigated whether CMBs-independent of other traditional markers of cerebral small vessel disease-are related to cognition. Chinese subjects from the population-based Singapore Chinese Eye Study, who failed an initial cognitive screening and were recruited into the ongoing Epidemiology of Dementia in Singapore Study, underwent neuropsychological testing and 3T brain magnetic resonance imaging. The presence and number of CMBs were graded using Brain Observer Microbleed Scale on susceptibility-weighted images. Other magnetic resonance imaging lesions that were graded included presence of lacunes, white matter lesion, and total brain volumes. A comprehensive neuropsychological battery was administered and cognitive function was summarized as composite and domain-specific Z-scores. Among 282 subjects, 91 had any CMBs (32.3%), of whom 36 (12.8%) had multiple CMBs. CMBs were-independent of cardiovascular risk factors and other markers of cerebral small vessel disease-significantly associated with poorer cognitive function as reflected by composite Z-score (mean difference per CMB increase: -0.06; 95% confidence interval: -0.11, -0.01] and with domain-specific Z-scores including executive function, attention, and visuoconstruction. Among Chinese subjects CMBs were, independent of other concomitant markers of cerebral small vessel disease, associated with poorer cognitive function.