The responses of the inflammatory marker, pentraxin 3, to dietary sodium and potassium interventions
The responses of the inflammatory marker, pentraxin 3, to dietary sodium and potassium interventions
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炎症标记物五聚蛋白 3 对膳食钠和钾干预的反应
DOI：
10.1111/jch.13273
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发表时间：
2018-05-01
影响因子：
2.8
通讯作者：
Mu, Jian-Jun
中科院分区：
文献类型：
--
作者：
Hu, Jia-Wen;Wang, Yang;Mu, Jian-Jun
正五聚蛋白-3是一种敏感的炎症标志物，在心血管疾病的发展中起着致病和心脏保护的双重作用。炎症与盐诱导的高血压密切相关。我们研究了正五聚蛋白-3对钠和钾补充的反应，以阐明正五聚蛋白-3在盐诱导的高血压中的潜在作用。共有来自中国西北地区的48名参与者入选。所有参与者都保持3天的正常饮食，随后是7天的低钠饮食，7天的高钠饮食和7天的高钠加钾饮食。使用ELISA评估正五聚蛋白-3的血浆浓度。与基线相比，低盐期间血浆正五聚蛋白-3显著降低（0.57 +/- 0.19ng/mL vs 0.72 +/- 0.33ng/mL，P=.012），高盐期间增加（0.68 +/- 0.26ng/mL vs 0.57 +/- 0.19ng/mL，P=.037）。补钾抑制了盐诱导的五聚蛋白-3增加（0.56 +/- 0.21ng/mL vs 0.68 +/- 0.26ng/mL，P= 0.015）。基线时Ln转化的正五聚蛋白-3与BMI（r=-0.349，P= 0.02）、DBP（r=-0.414，P= 0.005）、MAP（r=-0.360，P= 0.017）呈负相关。我们发现，在低钠和高钠期间，正五聚蛋白-3的ln转化浓度与24小时尿钠之间呈正相关（r= 0.269，P= 0.012），在高盐和高盐加钾期间，正五聚蛋白-3的ln转化浓度与24小时尿钾排泄呈负相关（r=-0.246，P= 0.02）。在调整混杂因素后，这些相关性仍然显著。正五聚蛋白-3反应在盐敏感个体中比耐盐个体更突出。膳食盐和钾的干预显着改变循环五聚蛋白-3。
Pentraxin-3 is a sensitive marker of inflammation that plays dual roles, pathogenic and cardioprotective, in the progression of cardiovascular diseases. Inflammation is intimately involved in salt-induced hypertension. We investigated the responses of pentraxin-3 to sodium and potassium supplementation to elucidate the potential role of pentraxin-3 in salt-induced hypertension. A total of 48 participants from northwest China were enrolled. All participants were maintained on a 3-day normal diet, which was sequentially followed by a 7-day low-sodium diet, a 7-day high-sodium diet, and a 7-day high-sodium plus potassium diet. Plasma concentrations of pentraxin-3 were assessed using ELISA. Plasma pentraxin-3 decreased significantly during the low-salt period compared to baseline (0.57 +/- 0.19ng/mL vs 0.72 +/- 0.33ng/mL, P=.012) and increased during the high-salt period (0.68 +/- 0.26ng/mL vs 0.57 +/- 0.19ng/mL, P=.037). Potassium supplementation inhibited salt-induced increase in pentraxin-3 (0.56 +/- 0.21ng/mL vs 0.68 +/- 0.26ng/mL, P=.015). Ln-transformed pentraxin-3 at baseline was inversely correlated with BMI (r=-.349, P=.02), DBP (r=-.414, P=.005), MAP (r=-.360, P=.017). We found a positive correlation between the ln-transformed concentrations of pentraxin-3 and 24-hour urinary sodium during low and high Na+ periods (r=.269, P=.012) and a negative relationship with 24hours urinary potassium excretion during high-salt and high-salt plus potassium periods (r=-.246, P=.02). These correlations remained significant after adjusting for confounders. Pentraxin-3 responses were more prominent in salt-sensitive individuals than salt-resistant individuals. Dietary salt and potassium interventions significantly altered circulating pentraxin-3.