The association between cognitive deficits and depressive symptoms in at-risk mental state: A comparison with first-episode psychosis
The association between cognitive deficits and depressive symptoms in at-risk mental state: A comparison with first-episode psychosis
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高危精神状态下认知缺陷与抑郁症状之间的关联：与首发精神病的比较
DOI：
10.1016/j.schres.2015.01.008
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发表时间：
2015
影响因子：
4.5
通讯作者：
Hiroo Matsuoka.
中科院分区：
文献类型：
--
作者：
Noriyuki Ohmuro;Kazunori Matsumoto;Masahiro Katsura;Chika Obara;Tatsuo Kikuchi;Yumiko Hamaie;Atsushi Sakuma;Kunio Iisuka;Fumiaki Ito;Hiroo Matsuoka.
在精神病的高危精神状态（ARMS）中，认知缺陷和抑郁症状的高患病率已被报道，但这些变量之间的关系仍不清楚。对50名ARMS患者、50名首发精神病（FEP）患者和30名健康对照者进行了精神分裂症认知能力简要评估（BACS）。采用阳性和阴性症状量表（PANSS）和贝克抑郁量表第二版（BDI-II）评定临床症状。比较三组之间BACS的综合z评分。在ARMS和FEP组中，比较了BACS综合z评分与临床症状指数之间的Pearson相关性。ARMS组（-2.82）和FEP组（-2.85）的BACS平均复合z评分显著低于HC组（P< 0.001）; ARMS组和FEP组之间无差异（P= 0.995）。认知缺陷和抑郁症状在ARMS组中显著相关（PANSS抑郁：r=-0.36，P = 0.010; BDI-II：r=-0.34，P = 0.02），而认知缺陷和阴性症状之间的相关性在FEP组中显著（r=-0.46，P = 0.001），在ARMS组中接近显著性（r=-0.25，P = 0.08）。ARMS组和FEP组认知功能障碍与抑郁症状的相关性差异有统计学意义（PANSS抑郁：Z= 2.50，P = 0.012; BDI-II：Z= 1.96，P = 0.0499）。因此，与FEP相比，认知缺陷和抑郁症之间的关系似乎是ARMS特有的。
Cognitive deficits and a high prevalence of depressive symptoms have been reported in at-risk mental state (ARMS) for psychosis, but the relationships between these variables remain unclear. The Brief Assessment of Cognition in Schizophrenia (BACS) was administered to 50 individuals with ARMS, 50 with first-episode psychosis (FEP), and 30 healthy controls (HC). Clinical symptoms were assessed by the Positive and Negative Syndrome Scale (PANSS) and the Beck Depression Inventory-2nd edition (BDI-II). Composite z-scores in BACS were compared between the three groups. Pearson correlations between composite z-scores on the BACS and indices of clinical symptoms were compared in the ARMS and FEP groups. The mean composite z-scores on the BACS for the ARMS (− 2.82) and FEP (− 2.85) groups were significantly lower than the HC group (P< 0.001); no differences between the ARMS and FEP groups emerged (P= 0.995). Cognitive deficits and depressive symptoms were significantly correlated in the ARMS group (PANSS depression:r= − 0.36,P= 0.010; BDI-II:r= − 0.34,P= 0.02), while the correlation between cognitive deficits and negative symptoms was significant in the FEP group (r= − 0.46,P= 0.001) and approached significance in the ARMS group (r= − 0.25,P= 0.08). The correlation between cognitive deficits and depressive symptoms significantly differed between the ARMS and FEP groups (PANSS depression:Z= 2.50,P= 0.012; BDI-II:Z= 1.96,P= 0.0499). Thus, a relationship between cognitive deficits and depression appears to be specific to ARMS compared to FEP.