Regulation of Aging and Longevity by Ion Channels and Transporters.
Regulation of Aging and Longevity by Ion Channels and Transporters.
复制标题
DOI：
10.3390/cells11071180
复制
发表时间：
2022-03-31
期刊：
影响因子：
6
通讯作者：
Venkatachalam K
中科院分区：
文献类型：
--
作者：
Venkatachalam K
尽管我们对与年龄相关的生理衰退机制的理解取得了重大进展，但我们将这些见解转化为延长人类健康寿命的可行策略的能力仍然有限。这种屏障存在的主要原因之一是，除了少数重要的例外，许多介导衰老的蛋白质已被证明是不可治愈的。这里提出的论点是，可以利用离子通道和转运蛋白对药理学操作的顺应性来开发新的治疗策略来对抗衰老。本文综述了离子通道和转运蛋白在衰老和长寿调节中的作用，通过它们对膜兴奋性、Ca2+稳态、线粒体和内溶酶体功能以及感觉刺激的转导的影响。其目的是为读者提供一个新兴的主题的理解，并促使进一步调查如何离子通道和转运的活动雕刻的细胞和有机体衰老的轨迹。
Despite significant advances in our understanding of the mechanisms that underlie age-related physiological decline, our ability to translate these insights into actionable strategies to extend human healthspan has been limited. One of the major reasons for the existence of this barrier is that with a few important exceptions, many of the proteins that mediate aging have proven to be undruggable. The argument put forth here is that the amenability of ion channels and transporters to pharmacological manipulation could be leveraged to develop novel therapeutic strategies to combat aging. This review delves into the established roles for ion channels and transporters in the regulation of aging and longevity via their influence on membrane excitability, Ca2+ homeostasis, mitochondrial and endolysosomal function, and the transduction of sensory stimuli. The goal is to provide the reader with an understanding of emergent themes, and prompt further investigation into how the activities of ion channels and transporters sculpt the trajectories of cellular and organismal aging.
登录
查看更多内容
影响因子：
3.7
作者：
Urbanelli L;Magini A;Ercolani L;Sagini K;Polchi A;Tancini B;Brozzi A;Armeni T;Principato G;Emiliani C
通讯作者：
Emiliani C
影响因子：
5.5
作者：
Bose S;He H;Stauber T
通讯作者：
Stauber T
影响因子：
5.3
作者：
Adams, Michelle M.;Shi, Lei;Brunso-Bechtold, Judy K.
通讯作者：
Brunso-Bechtold, Judy K.
影响因子：
4.5
作者：
Bjedov I;Cochemé HM;Foley A;Wieser D;Woodling NS;Castillo-Quan JI;Norvaisas P;Lujan C;Regan JC;Toivonen JM;Murphy MP;Thornton J;Kinghorn KJ;Neufeld TP;Cabreiro F;Partridge L
通讯作者：
Partridge L
影响因子：
64.5
作者：
Ballas, N;Grunseich, C;Mandel, G
通讯作者：
Mandel, G