Interleukin-15 and interleukin-2 enhance non-REM sleep in rabbits
Interleukin-15 and interleukin-2 enhance non-REM sleep in rabbits
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DOI：
10.1152/ajpregu.2001.281.3.r1004
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发表时间：
2001-09-01
影响因子：
2.8
通讯作者：
Krueger, JM
中科院分区：
文献类型：
--
作者：
Kubota, T;Brown, RA;Krueger, JM
白细胞介素（IL）-15和-2共享受体和信号转导途径（Jak-STAT途径）组分。IL-2在大鼠中具有致眠作用，但尚未在其他物种中进行测试。此外，IL-15对睡眠的影响迄今尚未被描述。我们研究了IL-15对家兔的催眠作用，并与IL-2进行了比较。在黑暗期开始时，脑室内注射三个剂量的IL-15或IL-2（10、100和500 ng）。此外，在光照期开始后3小时注射500 ng IL-15和IL-2。IL-15剂量依赖性地增加非快速眼动睡眠（NREMS）并诱导发热。IL-15在光照期间给药后抑制快速眼动睡眠（REMS）;然而，如果在黑暗开始时给药，所有剂量的IL-15均不能影响REMS。IL-2还剂量依赖性地增加NREMS和发热。IL-2抑制REMS，这种作用仅在光照期观察到。IL-15和IL-2在注射后最初9小时内增强脑电图（EEG）慢波，然后在注射后10-23小时内减少EEG慢波活动。目前的数据支持大脑细胞因子网络参与睡眠调节的观点。
Interleukin (IL)-15 and -2 share receptor- and signal-transduction pathway (Jak-STAT pathway) components. IL-2 is somnogenic in rats but has not been tested in other species. Furthermore, the effects of IL-15 on sleep have not heretofore been described. We investigated the somnogenic actions of IL-15 in rabbits and compared them with those of IL-2. Three doses of IL-15 or -2 (10, 100, and 500 ng) were injected intracerebroventriculary at the onset of the dark period. In addition, 500 ng of IL-15 and -2 were injected 3 h after the beginning of the light period. IL-15 dose dependently increased non-rapid eye movement sleep (NREMS) and induced fever. IL-15 inhibited rapid eye movement sleep (REMS) after its administration during the light period; however, all doses of IL-15 failed to affect REMS if given at dark onset. IL-2 also dose dependently increased NREMS and fever. IL-2 inhibited REMS, and this effect was observed only in the light period. IL-15 and -2 enhanced electroencephalographic (EEG) slow waves during the initial 9-h postinjection period, then, during hours 10-23 postinjection, reduced EEG slow-wave activity. Current data support the notion that the brain cytokine network is involved in the regulation of sleep.