Laminar distribution and arbor density of two functional classes of thalamic inputs to primary visual cortex.
Laminar distribution and arbor density of two functional classes of thalamic inputs to primary visual cortex.
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DOI：
10.1016/j.celrep.2021.109826
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发表时间：
2021-10-12
期刊：
影响因子：
8.8
通讯作者：
Reid RC
中科院分区：
文献类型：
--
作者：
Zhuang J;Wang Y;Ouellette ND;Turschak EE;Larsen RS;Takasaki KT;Daigle TL;Tasic B;Waters J;Zeng H;Reid RC
运动/方向敏感神经元和位置敏感神经元是小鼠视丘脑投射到初级视皮层（V1）的两种主要功能类型。运动/方向敏感输入是否优先针对V1中的浅层，而位置敏感输入优先针对中间层，这一点仍存在争议。在这里，通过使用钙成像来测量V1中的运动/方向敏感性和位置敏感性轴突的活动，我们在群体水平上找到了反对这些细胞类型特异性层状偏见的证据。此外，使用一种方法来重建轴突乔木与确定在体内的反应类型，我们表明，在单轴突水平，运动/方向敏感的轴突项目更密集的中间层比位置敏感的轴突。总的来说，我们的研究结果表明，运动/方向敏感的丘脑神经元项目广泛的V1在人口和单细胞水平的中间层，提供了进一步的洞察组织丘脑皮质投射在小鼠视觉系统。Zhuang等人，在群体和单轴突水平上研究小鼠初级视皮层中功能特异性丘脑皮质投射模式。他们发现，运动/方向敏感轴突广泛投射到初级视觉皮层的中间层，挑战了现有的假设，提出了这些轴突的表面靶向偏见。
Motion/direction-sensitive and location-sensitive neurons are the two major functional types in mouse visual thalamus that project to the primary visual cortex (V1). It is under debate whether motion/direction-sensitive inputs preferentially target the superficial layers in V1, as opposed to the location-sensitive inputs, which preferentially target the middle layers. Here, by using calcium imaging to measure the activity of motion/direction-sensitive and location-sensitive axons in V1, we find evidence against these cell-type-specific laminar biases at the population level. Furthermore, using an approach to reconstruct axon arbors with identified in vivo response types, we show that, at the single-axon level, the motion/direction-sensitive axons project more densely to the middle layers than the location-sensitive axons. Overall, our results demonstrate that motion/direction-sensitive thalamic neurons project extensively to the middle layers of V1 at both the population and single-cell levels, providing further insight into the organization of thalamocortical projection in the mouse visual system. Zhuang et al., investigate the functionally specific thalamocortical projection patterns in mouse primary visual cortex at both the population and single-axon levels. They find that the motion/direction-sensitive axons project extensively to the middle layers of primary visual cortex, challenging an existing hypothesis proposing a superficial targeting bias of these axons.
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