Multimodality correlative study of canine brain tumors. Proton magnetic resonance spectroscopy, positron emission tomography, and histology.
Multimodality correlative study of canine brain tumors. Proton magnetic resonance spectroscopy, positron emission tomography, and histology.
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犬脑肿瘤的多模态相关研究。
DOI：
10.1097/00004424-199406000-00001
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发表时间：
1994
影响因子：
6.7
通讯作者：
SamphilipoJr,MA
中科院分区：
文献类型：
--
作者：
Anderson,JH;Strandberg,JD;Wong,DF;Conti,PS;Barker,PB;Blackband,SJ;Hilton,J;Natarajan,TK;Dannals,RF;SamphilipoJr,MA
合理性和连续性：采用质子磁共振波谱（1 H-MRS）、正电子发射断层扫描（PET）和组织学方法研究了诱导犬脑肿瘤的结构/功能关系。植入犬脑肿瘤的质子磁共振波谱和PET数据与MRS和PET感兴趣区域（ROI）内组织成分的定量分析相关。采用线性回归分析将1H-MRS和PET数据与ROI内的肿瘤百分比和总病变百分比（包括肿瘤加上相关病理学即水肿、囊肿、出血、炎症）相关联。058），以及肿瘤量加相关病理学（P=. 032)在王。总肌酸浓度与ROI内的肿瘤量及肿瘤加相关病理学检查间接相关（P<0. 05）。05）。乳酸浓度与肿瘤量直接相关（P=. 053)肿瘤量及相关病理改变（P=. 058)在王。
RATIONALE AND OBJECTIVES.Structural/functional relationships in an induced canine brain tumor were studied using proton-magnetic resonance spectroscopy (1 H-MRS), positron emission tomography (PET), and histology.METHODS.Proton-MRS and PET data of implanted canine brain tumors were correlated with quantitative analysis of the tissue composition within the MRS and PET regions of interest (ROIs). Linear regression analysis was employed to correlate the 1 H-MRS and PET data with the percent tumor and the percent total lesion (comprising tumor plus associated pathology ie, edema, cysts, hemorrhage, inflammation) within the ROI.RESULTS.Using 1 H-MRS, N-acetyl aspartate concentrations were indirectly correlated with the amount of tumor (P=. 058), as well as the amount of tumor plus associated pathology (P=. 032) within the ROI. Total creatine concentrations were indirectly correlated with the amount of tumor and the amount of tumor plus associated pathology within the ROI (P<. 05). Lactate concentrations were directly correlated with the amount of tumor (P=. 053) and the amount of tumor plus associated pathology (P=. 058) within the ROI.