Effects of middle-ear immaturity on distortion product otoacoustic emission suppression tuning in infant ears
Effects of middle-ear immaturity on distortion product otoacoustic emission suppression tuning in infant ears
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DOI：
10.1121/1.2359237
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发表时间：
2006-12-01
影响因子：
2.4
通讯作者：
Keefe, Douglas H.
中科院分区：
文献类型：
--
作者：
Abdala, Carolina;Keefe, Douglas H.
畸变产物耳声发射（DPOAE）耳蜗功能的措施，包括DPOAE抑制调谐曲线和输入/输出（I/O）功能，是不像成人在人类婴儿。这些发现表明，耳蜗放大器可能是功能不成熟的新生儿。然而，许多非耳蜗因素影响DPOAE，必须加以考虑。本研究探讨是否年龄差异DPOAE I/O功能记录从婴儿和成人耳反映成熟的耳道/中耳功能或耳蜗力学。建立了一个基于线性中耳传输和非线性耳蜗产生的模型来拟合成人DPOAE I/O数据。通过仅改变与中耳传输相关的那些模型参数（并将耳蜗参数保持在成人值），该模型成功地拟合了从出生到6个月大的婴儿的I/O数据。这表明耳蜗力学在出生时就已经成熟。该模型预测了通过未成熟的耳道和中耳的刺激能量的衰减，并评估是否不成熟的前向传输可以解释婴儿和成人DPOAE抑制之间的差异始终观察到。结果表明，一旦不成熟的补偿，提供婴儿与相对增加的主要音调水平，DPOAE抑制调谐在f2 = 6000 Hz的成人和婴儿是相似的。2006年，美国声学学会。
Distortion product otoacoustic emission (DPOAE) measures of cochlear function, including DPOAE suppression tuning curves and input/output (I/O) functions, are not adultlike in human infants. These findings suggest the cochlear amplifier might be functionally immature in newborns. However, many noncochlear factors influence DPOAEs and must be considered. This study examines whether age differences in DPOAE I/O functions recorded from infant and adult ears reflect maturation of ear-canal/middle-ear function or cochlear mechanics. A model based on linear middle-ear transmission and nonlinear cochlear generation was developed to fit the adult DPOAE I/O data. By varying only those model parameters related to middle-ear transmission (and holding cochlear parameters at adult values), the model successfully fitted I/O data from infants at birth through age 6 months. This suggests that cochlear mechanics are mature at birth. The model predicted an attenuation of stimulus energy through the immature ear canal and middle ear, and evaluated whether immaturities in forward transmission could explain the differences consistently observed between infant and adult DPOAE suppression. Results show that once the immaturity was compensated for by providing infants with a relative increase in primary tone level, DPOAE suppression tuning at f2 = 6000 Hz was similar in adults and infants. 0 2006 Acoustical Society of America.