Fourteen-year longitudinal study of vascular risk factors, APOE genotype, and cognition: The ARIC MRI Study
Fourteen-year longitudinal study of vascular risk factors, APOE genotype, and cognition: The ARIC MRI Study
复制标题
DOI：
10.1016/j.jalz.2009.01.027
复制
发表时间：
2009-05-01
影响因子：
14
通讯作者：
Coker, Laura H.
中科院分区：
文献类型：
--
作者：
Knopman, David S.;Mosley, Thomas H.;Coker, Laura H.
背景：中风、血管危险因素和载脂蛋白 E (APOE) 基因型与老年人认知能力下降有关，但表明这些因素早在中年就影响认知的明确证据是有限的。目的：我们在中年招募的社区动脉粥样硬化风险 (ARIC) 研究队列中，经过 14 年的随访，描述了 APOE 基因型、中风和血管危险因素与认知变化的关系。方法：参与者包括一个子集ARIC 研究的参与者接受了认知功能和血管危险因素的评估。 1990-1992 年和 2004-2006 年期间进行了四次认知评估。认知评估包括延迟单词回忆 (DWR) 测试、数字符号替换 (DSS) 测试和单词流利度 (WF) 测试。在 1990-1992 年的基线访视期间评估了血管危险因素。在 14 年的随访期间记录了中风事件。结果：共有 1130 名参与者（平均年龄 59±4.3 [SD] 岁；62% 为女性；52% 为非裔美国人）提供纵向数据。在针对年龄、教育程度、性别和种族进行调整的多变量随机效应线性模型中，危险因素糖尿病和 APOE epsilon 4 基因型与 DSS 测试成绩下降独立相关（均为 P
Background: Strokes, vascular risk factors, and apolipoprotein E (APOE) genotype are associated with cognitive decline in the elderly, but definitive evidence that these affect cognition as early as middle age is limited.Objective: We describe the relationships of APOE genotype, stroke, and vascular risk factors with cognitive change over a 14-year follow-up in the Atherosclerosis Risk in Communities (ARIC) Study cohort recruited while in middle age.Methods: Participants included a subset of the ARIC Study Who underwent assessments of cognitive function and vascular risk factors. Four cognitive assessments were performed between 1990-1992 and 2004-2006. Cognitive assessments included the Delayed Word Recall (DWR) Test, the Digit Symbol Substitution (DSS) Test, and the Word Fluency (WF) Test. Vascular risk factors were assessed during the baseline visit in 1990-1992. Incident stroke was recorded over the 14 years of follow-up.Results: There were 1130 participants (mean age, 59 4.3 [SD] years; 62% women; 52% African-American) with longitudinal data. In multivariate, random-effects linear models adjusted for age, education, gender, and race, the risk factors diabetes and APOE epsilon 4 genotype were independently associated with a decline in performance on the DSS test (both P