Structural considerations of the snake venom metalloproteinases, key members of the M12 reprolysin family of metalloproteinases
Structural considerations of the snake venom metalloproteinases, key members of the M12 reprolysin family of metalloproteinases
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DOI：
10.1016/j.toxicon.2005.02.012
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发表时间：
2005-06-15
期刊：
影响因子：
2.8
通讯作者：
Serrano, SMT
中科院分区：
文献类型：
--
作者：
Fox, JW;Serrano, SMT
蛋白酶在蝰蛇咬伤相关病理中的重要性早已受到重视。在过去的40年中，大量研究明确表明毒液中的金属蛋白酶（蛇毒金属蛋白酶；SVMPs）在出血、水肿、低血压、血容量减少、炎症和坏死等症状的发展中起着关键作用。尽管有如此丰富的信息，但关于导致活性多样性的各种SVMPs的结构基础仍有许多未解决的问题。在这篇简短的综述中，我们不会试图对SVMPs的结构研究进行详尽的整理；然而，我们将简要概述SVMPs的结构分类，并将它们与金属蛋白酶的去整合素家族的其他成员——解聚素样金属蛋白酶（ADAMs）联系起来。文中所提供的信息不允许对SVMP功能多样性的结构基础得出具体结论，但我们的目标是它将有助于提出可通过实验验证的假设。读者将会发现，不同的SVMP类别和亚类呈现出非常有趣的结构特征，这些特征为它们的功能特性提供了见解。（c）2005爱思唯尔有限公司。保留所有权利。
The importance of proteinases in the pathologies associated with Viperid envenoming has long been appreciated. Over the past 40 years substantial research has clearly implicated metalloproteinases in the venom (snake venom metalloproteinases; SVMPs) as playing key roles in the development of such symptoms as hemorrhage, edema, hypotension, hypovolemia, inflammation and necrosis. In spite of this wealth of information there are still many unresolved questions pertaining to the structural basis for the various SVMPS giving rise to the diversity of activities. In this short review we will not attempt to provide an exhaustive collation of structural studies on the SVMPs; however, we will give a brief outline of the structural classification of the SVMPs; as well as relate them to the other members of the reprolysin family of metalloproteinases, the ADAMs. The information put forth in the text does not allow specific conclusions to be drawn on the structural basis for SVMP functional diversity, but it is our goal that it will allow for the development of testable hypotheses that can be experimentally pursued. What the reader will observe is that there are very interesting structural features displayed by the various SVMP classes and subclasses that provide insight into their functional characteristics. (c) 2005 Elsevier Ltd. All rights reserved.