ACTIVATION OF PROGRAMMED CELL-DEATH IN THE RAT VENTRAL PROSTATE AFTER CASTRATION
ACTIVATION OF PROGRAMMED CELL-DEATH IN THE RAT VENTRAL PROSTATE AFTER CASTRATION
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DOI：
10.1210/endo-122-2-552
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发表时间：
1988-02-01
期刊：
影响因子：
4.8
通讯作者：
ISAACS, JT
中科院分区：
文献类型：
--
作者：
KYPRIANOU, N;ISAACS, JT
去势后大鼠腹侧前列腺的快速退化是一个主动的过程，是由于雄激素对前列腺细胞死亡的抑制作用被消除而开始的。目前的研究表明，去势诱导的雄激素剥夺后，一系列时间离散的生化事件被激活，导致大鼠腹侧前列腺内的雄激素依赖性细胞的子集的快速程序性死亡。这些生化步骤包括：1）细胞核雄激素受体保留的迅速丧失;去势后12小时，在腹侧前列腺核中不再检测到雄激素受体; 2）细胞核DNA初始片段化为低分子量（
The rapid involution of the rat ventral prostate after castration is an active process initiated by removal of the inhibitory effects of androgen on prostatic cell death. The present studies demonstrate that after castration-induced androgen deprivation a series of temporally discrete biochemical events are activated which result in the rapid programmed death of the subset of androgen-dependent cells within the rat ventral prostate. These biochemical steps involve 1) rapid loss of nuclear androgen receptor retention; by 12 h after castration, androgen receptors are no longer detectable in ventral prostatic nuclei; 2) an initial fragmentation of nuclear DNA into low mol wt (