Gene therapy for lower urinary tract dysfunction.
Gene therapy for lower urinary tract dysfunction.
复制标题
下尿路功能障碍的基因治疗。
DOI：
10.1111/j.1442-2042.2012.03226.x
复制
发表时间：
2013
期刊：
影响因子：
2.6
通讯作者：
Funahashi Y.
中科院分区：
文献类型：
--
作者：
Yoshimura N;Miyazato M;Sasaki K;Yokoyama H;Oguchi T;Chancellor MB;Funahashi Y.
下尿路功能障碍是由周围器官的功能和病理生理变化引起的，包括尿路上皮和逼尿肌，以及周围和中枢神经系统。最近在这一领域的研究增加了我们对下尿路功能障碍机制的理解，新药的开发，导致了更多的治疗选择和改变了下尿路症状的医疗保健。然而，临床医生仍然经常遇到与传统治疗方式不同的难治和耐药病例。对于这种情况，针对下尿路及其传入途径的基因治疗有望提供一种新的治疗方法。因此，本文就下尿路功能障碍基因治疗的可能性和现状作一综述。
Lower urinary tract dysfunction is caused by functional and pathophysiological alterations of the peripheral organs, including the urothelium and detrusor smooth muscle, as well as peripheral and central nervous systems. Recent research in this field has increased our understanding of the mechanisms of lower urinary tract dysfunction, and new drugs have been developed, leading to increased treatment options and changing medical care for lower urinary tract symptoms. Nevertheless, clinicians still often experience refractory and treatment‐resistant cases against conventional therapeutic modalities. For such cases, gene therapy targeting for the lower urinary tract and its afferent pathway is anticipated to offer a new therapeutic approach. Therefore, in this article, we review the possibility and current status of gene therapy for lower urinary tract dysfunction.