Angiotensin on Vascular Smooth Muscle
Angiotensin on Vascular Smooth Muscle
复制标题
血管紧张素对血管平滑肌的作用
DOI：
10.1007/978-3-642-65600-2_23
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发表时间：
1974
影响因子：
2.9
通讯作者：
D. Bohr
中科院分区：
文献类型：
--
作者：
D. Bohr
血管紧张素是一种能引起血管平滑肌收缩的强效激动剂。在完整生物体中由此产生的血管收缩具有重要的生理和病理生理意义，这在最近的一些综述中得到了反映（Peart, 1965； Gross等人，1968；Somlyo和Somlyo， 1970）。这些广泛而出色的调查减轻了我的负担。在这些评论和我所涉及的最近的文献中，对这个已经成熟的领域的先驱调查给予了赞扬；在当前的评论中省略了历史调查。虽然我的报道仅限于过去几年，但我发现，在这一时期，研究已经足够活跃，足以证明试图描述当前的艺术状态是合理的。关于血管紧张素对血管平滑肌的影响的研究主要是描述性的，然而，这些信息已经积累了足够多，并且逐渐到位，因此一些机械的解释现在似乎是合适的。
Angiotensin is a potent agonist that causes contraction of vascular smooth muscle. The resultant vasoconstriction in the intact organism has important physiological and pathophysiological implications which are reflected in a number of recent reviews (Peart, 1965; Gross et al., 1968; Somlyo and Somlyo, 1970). These extensive and excellent surveys have lightened my burden. In these reviews and in the recent literature I have covered, credit is given to the pioneer investigations in this already mature field; historical survey is omitted in the current review. Although I have restricted coverage to the past few years, I have found that in this period research has been adequately active to justify an attempt to describe the current state of the art. Contributions dealing with the effect of angiotensin on vascular smooth muscle have been primarily descriptive, yet enough of these bits of information have accumulated and are falling into place so that some mechanistic interpretations now seem appropriate.