Top-down and bottom-up fabrication techniques for hydrogel based sensing and hormone delivery microdevices.
Top-down and bottom-up fabrication techniques for hydrogel based sensing and hormone delivery microdevices.
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基于水凝胶的传感和激素输送微器件的自上而下和自下而上的制造技术。
DOI：
10.1109/iembs.2009.5332511
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发表时间：
2009
期刊：
影响因子：
--
通讯作者：
Ziaie,Babak
中科院分区：
文献类型：
--
作者：
Siegel,RonaldA;Nuxoll,EricE;Hillmyer,MarcA;Ziaie,Babak
我们回顾了一组研究处理分子（葡萄糖）传感和激素的传递，其中作为葡萄糖浓度的函数的水凝胶的溶胀和收缩起着核心作用。将水凝胶限制在微加工结构中允许其化学机械行为的转导。已经使用含有苯基硼酸侧链的水凝胶设计了用于无线葡萄糖感测和闭环胰岛素递送控制的原型微型装置。虽然这些器件表现出所需的响应，但需要改进的响应时间，从而避免进一步小型化。在单独的应用中，葡萄糖氧化酶通过pH敏感性水凝胶膜的几何限制建立了非线性反馈回路，当系统暴露于恒定的葡萄糖浓度时，该非线性反馈回路能够实现有节奏的膨胀/收缩循环。后一种系统可用于递送促性腺激素释放激素，对于促性腺激素释放激素，分泌的节律性对于治疗功能是必不可少的。
We review a set of studies dealing with molecular (glucose) sensing and hormone delivery, in which the swelling and shrinking of a hydrogel as a function of glucose concentration play a central role. Confining hydrogels in microfabricated structures permits transduction of their chemomechanical behaviors. Prototype microdevices for wireless glucose sensing and closed loop insulin delivery control have been designed using hydrogels containing phenylboronic acid sidechains. While these devices exhibit desired responses, improved response time is needed, warranting further miniaturization. In a separate application, geometric confinement of glucose oxidase by a pH-sensitive hydrogel membrane sets up a nonlinear feedback loop which enables rhythmic swell/shrink cycles when the system is exposed to a constant glucose concentration. The latter system may be applied to delivery of gonadotropin release hormone, for which rhythmicity of secretion is essential for therapeutic function.