Muscle magnetic resonance imaging of denervation and reinnervation: correlation with electrophysiology and histology
Muscle magnetic resonance imaging of denervation and reinnervation: correlation with electrophysiology and histology
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DOI：
10.1016/j.expneurol.2003.10.012
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发表时间：
2004-02-01
影响因子：
5.3
通讯作者：
Bendszus, M
中科院分区：
文献类型：
--
作者：
Wessig, C;Koltzenburg, M;Bendszus, M
在几个临床和实验研究中，已经描述了去神经肌肉在磁共振成像(MRI)上信号增加。在这里，我们研究了去神经支配和随后的神经再支配过程中T2松弛时间变化的时间进程，并将结果与电生理学和定量组织学相关联。失神经支配后48h，肌肉T2松弛时间延长，与肌电自发活动相平行。组织学上，在那个时间点，毛细血管明显增大，表明血容量增加。肌电显示松弛时间变化在神经再生开始后3周达到高峰。随后，T2延长恢复正常，直到再生开始后10周，这与组织学上毛细血管增大的消退有关。MRI能很好地反映去神经和再神经支配后的电生理变化，因此可以作为电生理学的辅助手段。磁共振弛豫时间改变的病理生理学基础主要是毛细血管床的增大。(C)2003 Elsevier Inc.保留所有权利。
A signal increase in denervated muscle on magnetic resonance imaging (MRI) has been described in several clinical and experimental studies. Here, we studied the time course of T2-relaxation time changes in denervation and subsequent reinnervation in a rat model and correlated the findings with electrophysiology and quantitative histology. A prolongation of the T2 relaxation time in muscles was present 48 h after denervation, which was paralleled by spontaneous activity on electromyography (EMG). Histologically, there was a marked enlargement of the capillaries at that time point, indicating increased blood volume. The relaxation time changes peaked 3 weeks after beginning of nerve regeneration identified by EMG. Subsequently, the T2 prolongation normalized until 10 weeks after beginning of regeneration which was associated with a histological regression of the capillary enlargement. MRI closely mirrors the electrophysiological changes following denervation and reinnervation and may thus be used as adjunct to electrophysiology. The pathophysiological basis for the MR relaxation time changes is predominantly the enlargement of the capillary bed. (C) 2003 Elsevier Inc. All rights reserved.