In vitro fertilization in Japan - early days of in vitro fertilization and embryo transfer and future prospects for assisted reproductive technology.
In vitro fertilization in Japan - early days of in vitro fertilization and embryo transfer and future prospects for assisted reproductive technology.
复制标题
DOI：
10.2183/pjab.90.184
复制
发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Suzuki M
中科院分区：
文献类型：
--
作者：
Suzuki M
体外受精(IVF)、胚胎移植(ET)等辅助生殖技术(ART)已成为治疗不孕症的重要手段。1978年，基于罗伯特·爱德华兹博士和帕特里克·斯特普托博士开发的技术，世界上第一个试管受精-ET婴儿出生。)在日本，东北大学医学院的铃木雅幸教授于1983年报道了第一例体外受精-胚胎移植的出生。)IVF-ET是一种用于实现怀孕的程序，它包括从不孕妇女身上提取卵母细胞，在体外使其受精，并将受精卵转移到患者的宫腔(图1)。自从第一个成功的IVF-ET报告以来，许多与ART相关的技术得到了发展和完善，如卵母细胞和胚胎的冷冻保存、配子输卵管内移植(GIFT)和微授精(MicroInformation)(表1)。在这里，我们描述了导致人类应用的体外受精-胚胎移植基础研究的历史，第一个体外受精-胚胎移植婴儿是如何在日本出生的，日本抗逆转录病毒治疗的现状，与抗逆转录病毒治疗相关的问题，以及抗逆转录病毒治疗的未来前景。
Assisted reproductive technology (ART) such as in vitro fertilization (IVF) and embryo transfer (ET) has been essential in the treatment of infertility. The world’s first IVF-ET baby was born in 1978 based on the technique developed by Dr. Robert Edwards and Dr. Patrick Steptoe.) In Japan, the first IVF-ET birth was reported in 1983 by Prof. Masakuni Suzuki at Tohoku University School of Medicine.) IVF-ET is a procedure used to achieve pregnancy that consists of extracting oocytes from an infertile woman, fertilizing them in vitro, and transferring fertilized eggs into the patient’s uterine cavity (Fig. 1). Since the first report of successful IVF-ET, numerous techniques related to ART, such as cryopreservation of oocytes and embryos, gamete intrafallopian transfer (GIFT), and microinsemination, have been developed and refined (Table 1). Herein we describe the history of basic research in IVF-ET that led to human applications, how the birth of the first IVF-ET baby was achieved in Japan, the current status of ART in Japan, issues related to ART, and future prospects for ART.