Amyloid β-protein oligomers and Alzheimer's disease.
Amyloid β-protein oligomers and Alzheimer's disease.
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DOI：
10.1186/alzrt226
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Teplow DB
中科院分区：
文献类型：
--
作者：
Hayden EY;Teplow DB
低聚物级联假说认为低聚物是阿尔茨海默病的初始病理因子，这一假说几乎取代了淀粉样蛋白级联假说，后者认为纤维是阿尔茨海默病的关键病因因子。我们在这里回顾了淀粉样蛋白β-低聚物的体内、体外和计算机研究的结果，并讨论了在评估这些结果时应考虑的重要注意事项。本文分为四个部分，反映了该领域用于更好地理解低聚物的主要方法：(1)尝试在体内原位定位和检查低聚物；也就是说，不把这些物种从它们的环境中移除；(2)涉及从人类或动物组织中提取的低聚物及其体外特性的后续表征的研究；(3)利用还原论方法在相对简单的体外生物物理系统中合成和研究低聚物；(4)硅低聚物的计算研究。这些多重正交方法揭示了淀粉样β-蛋白的分子和细胞生物学。然而，尽管这些方法提供了丰富的信息，淀粉样蛋白β-低聚体系统仍然是一个谜。
The oligomer cascade hypothesis, which states that oligomers are the initiating pathologic agents in Alzheimer’s disease, has all but supplanted the amyloid cascade hypothesis, which suggested that fibers were the key etiologic agents in Alzheimer’s disease. We review here the results of in vivo, in vitro and in silico studies of amyloid β-protein oligomers, and discuss important caveats that should be considered in the evaluation of these results. This article is divided into four sections that mirror the main approaches used in the field to better understand oligomers: (1) attempts to locate and examine oligomers in vivo in situ; that is, without removing these species from their environment; (2) studies involving oligomers extracted from human or animal tissues and the subsequent characterization of their properties ex vivo; (3) studies of oligomers that have been produced synthetically and studied using a reductionist approach in relatively simple in vitro biophysical systems; and (4) computational studies of oligomers in silico. These multiple orthogonal approaches have revealed much about the molecular and cell biology of amyloid β-protein. However, as informative as these approaches have been, the amyloid β-protein oligomer system remains enigmatic.
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DOI：
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发表时间：
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影响因子：
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发表时间：
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DOI：
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发表时间：
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影响因子：
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