Regulatory role of T cells in IgG antibody formation and immune memory to type III Pneumococcal polysaccharide.
Regulatory role of T cells in IgG antibody formation and immune memory to type III Pneumococcal polysaccharide.
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T 细胞在 IgG 抗体形成和对 III 型肺炎球菌多糖的免疫记忆中的调节作用。
DOI：
10.4049/jimmunol.113.6.1909
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发表时间：
1974
影响因子：
4.4
通讯作者：
H. Braley‐Mullen
中科院分区：
文献类型：
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作者：
H. Braley‐Mullen
用III型肺炎球菌多糖(S3)免疫的小鼠只产生IgM抗体，在第二次攻击该抗原后没有证据表明免疫记忆。然而，当经历同种异体效应的小鼠用S3免疫时，一些但不是所有品系的小鼠都会产生抗体。当小鼠用胸腺(T)依赖的抗原S3与绵羊红细胞偶联(S3-SRBC)免疫两次时，也会产生S3特异性的IgG抗体，这些小鼠会形成S3特异性的免疫记忆。由于S3-SRBC的同种异体效应和免疫预期会导致同种异体抗原特异性或携带者特异性T细胞的激活，结果表明T细胞在免疫球蛋白抗体的形成和对T非依赖性抗原的免疫记忆中发挥重要的调节作用。用S3免疫小鼠并用抗淋巴细胞血清(ALS)处理后，也可产生免疫球蛋白G抗体。由于ALS可能会移除抑制性T细胞，因此推测可能存在S3特异性的“辅助”T细胞，但当S3单独免疫小鼠时，抑制性细胞通常会阻止它们的表达。
Mice immunized with Type III pneumococcal polysaccharide (S3) produce only IgM antibodies and there is no evidence for immune memory after a second challenge with the antigen. However, when mice undergoing an allogeneic effect are immunized with S3, IgG antibody is produced by some, but not all, strains of mice. Mice also produce IgG antibody specific for S3 when they are immunized twice with a thymus (T) dependent form of antigen, S3 coupled to sheep erythrocytes (S3-SRBC), and these mice develop S3-specific immune memory. Since the allogeneic effect and immunization with S3-SRBC would be expected to result in activation of alloantigen-specific or carrier-specific T cells, the results suggest that T cells play an important regulatory role in IgG antibody formation and immune memory for a presumably T-independent antigen. IgG antibody was also produced when mice were immunized with S3 and treated with anti-lymphocyte serum (ALS). Since ALS presumably removes suppressor T cells it is suggested that S3-specific “helper” T cells may exist but that suppressor cells normally prevent them from being expressed when mice are immunized with S3 alone.