The role of microRNAs in colorectal cancer.
The role of microRNAs in colorectal cancer.
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DOI：
10.1097/ppo.0b013e318258b78f
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发表时间：
2012-05
期刊：
影响因子：
--
通讯作者：
Harris CC
中科院分区：
文献类型：
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作者：
Schetter AJ;Okayama H;Harris CC
在过去的十年中，已经清楚异常microRNA表达在结直肠癌（CRC）的发生和发展中具有功能性作用。特定的microRNA可以作为肿瘤抑制因子或癌基因，这取决于它们表达的细胞环境。microRNA的表达在CRC中可重复地改变，并且它们的表达模式与CRC的诊断、预后和治疗结果相关。研究已经开始检查microRNA相关多态性的关联及其与CRC发病率和预后的关联，以及使用循环microRNA或粪便microRNA表达作为非侵入性早期检测生物标志物的可能性。这些数据表明microRNA可能是CRC潜在的分子分类器、早期检测生物标志物和治疗靶点。在这里，我们将回顾证明microRNA在CRC中作用的证据。
Over the last decade, it has become clear that aberrant microRNA expression has a functional role in the initiation and progression of colorectal cancer (CRC). Specific microRNAs can act as either tumor suppressors or oncogenes depending on the cellular environment in which they are expressed. The expression of microRNAs is reproducibly altered in CRC and their expression patterns are associated with diagnosis, prognosis and therapeutic outcome in CRC. Studies have begun to examine the association of microRNA related polymorphisms and their association with CRC incidence and prognosis as well as the possibility of using circulating microRNAs or fecal microRNA expression as non-invasive early detection biomarkers. These data suggest that microRNAs may be potential molecular classifiers, early detection biomarkers and therapeutic targets for CRC. Here, we will review the evidence demonstrating a role of microRNAs in CRC.