Transient metabolic changes observed with proton MR spectroscopy in normal human brain after radiation therapy
Transient metabolic changes observed with proton MR spectroscopy in normal human brain after radiation therapy
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DOI：
10.1016/s0360-3016(97)00714-1
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发表时间：
1998-01-15
影响因子：
7
通讯作者：
Le Bas, JF
中科院分区：
文献类型：
--
作者：
Estève, F;Rubin, C;Le Bas, JF
目的：观察正常人脑放射治疗后质子磁共振波谱（H-1-MRS）的时程变化。我们对11例接受单纯外照射治疗的脑肿瘤患者进行了为期8个月的随访，他们在接受任何放射治疗前和开始放射治疗后1、4和8个月进行了质子MRS扫描，患者肿瘤区接受60戈伊分次照射6周，对侧正常大脑半球接受20 ~ 50戈伊照射，主要代谢物浓度（N-乙酰天冬氨酸（NAA）、胆碱化合物（Cho）、肌酸（Cr）和乳酸（Lac）通过峰拟合后的峰面积来评价，通过处理给定代谢物的峰面积与所有光谱峰面积之和的比值获得归一化值（NV）;比率（NAA/Cho、NAA/Cr和Cho/Cr）进行了处理。1例患者在原发性肾腺癌切除术后接受了全脑放疗（30戈伊），结果：放射治疗开始后4个月，正常脑组织中观察到以下变化：NAA/Cho、NAA/Cr比值及NAA（NV）降低，胆碱（NV）升高，4个月后恢复正常。H-1-MRS具有在体检测和评价放射治疗对正常人脑的早期代谢不良效应的潜力。这些变化在放射治疗开始后4个月是显著的，并且似乎随着时间的推移而消退。(C)1998年爱思唯尔科学公司
Purpose: To observe the time course of the proton magnetic resonance spectroscopy (H-1-MRS) variations due to radiation therapy on normal human brain,Methods and Materials: We followed 11 patients receiving an exclusive external radiation therapy for brain tumor for 8 months, They underwent proton MRS scans before any radiation exposure and 1, 4, and 8 months after they began the radiation therapy, The patients received 60 Gy in tumoral area fractionated over 6 weeks, The contralateral normal brain hemisphere received a radiation dose from 20 to 50 Gy, The main metabolite concentrations (N-acetylaspartate (NAA), choline compounds (Cho), creatine (Cr), and lactate (Lac) were evaluated by the areas of the peaks after peak fitting, Normalized values (NV) were obtained by processing the ratio of the peak area of a given metabolite to the sum of all the spectrum peak areas; ratios (NAA/Cho, NAA/Cr, and Cho/Cr) were processed, One patient, who received panencephalic radiotherapy (30 Gy) after metastasectomy from a primary kidney adenocarcinoma, has been monitored with H-1-MRS eight times for 6 months to observe the onset of the metabolic changes.Results: Changes were observed in irradiated normal brain tissue 4 months after radiation therapy began: the NAA/Cho and NAA/Cr ratios and the NAA (NV) decreased while the Choline (NV) increased, Four months later, normal values were recovered,Conclusion: H-1-MRS has the potentiality to detect and to evaluate in vivo early adverse metabolic effects of radiation therapy in the normal human brain. These changes are significant 4 months after the radiation therapy began and appear to resolve over time. (C) 1998 Elsevier Science Inc.