Comparison of single‐ and multiple‐dose cefazolin as prophylaxis for transurethral enucleation of prostate: A multicenter, prospective, randomized controlled trial by the Japanese Research Group for Urinary Tract Infection
Comparison of single‐ and multiple‐dose cefazolin as prophylaxis for transurethral enucleation of prostate: A multicenter, prospective, randomized controlled trial by the Japanese Research Group for Urinary Tract Infection
复制标题
单剂量和多剂量头孢唑啉预防经尿道前列腺剜除术的比较：日本尿路感染研究小组进行的多中心、前瞻性、随机对照试验
DOI：
10.1111/iju.14181
复制
发表时间：
2020
影响因子：
2.6
通讯作者：
Yam
中科院分区：
文献类型：
--
作者：
Togo Yoshikazu;Fukui Koji;Ueda Yasuo;Kanamaru Sojun;Shimizu Yosuke;Wada Koichiro;Sadahira Takuya;Yamada Yusuke;Matsumoto Masahiro;Hamasuna Ryoichi;Ishikawa Kiyohito;Takai Manabu;Maekawa Yuka;Yasuda Mitsuru;Kokura Koji;Kondoh Nobuyuki;Takiuchi Hidekazu;Yam
目的比较2015年1月至2018年12月经尿路前列腺摘除术患者应用抗菌药物预防的最佳给药时间。方法采用随机对照试验，比较2015年1月至2018年12月，无脓尿或菌尿的良性前列腺增生症患者单次和多次(3天)应用头孢唑林治疗前列腺增生症患者围手术期泌尿生殖道感染的差异。所有人都接受了抗菌素预防，并被随机分为单剂(n=1010)或多剂(n=10102)治疗组。经尿道前列腺摘除术后泌尿生殖道感染的发生率为1.5%，单剂组为1.0%，多剂组为2.0%，差异无统计学意义(P=0.00)。结论对于术前无脓尿或菌尿的患者，单剂预防性应用抗菌药物是足够的。
ObjectivesTo compare the optimal administration period of antimicrobial prophylaxis in patients undergoing transurethral enucleation of the prostate for benign prostatic hyperplasia.MethodsWe carried out a randomized controlled trial to compare the differences in incidence of perioperative genitourinary tract infection between single and multiple (3 days) administrations of cefazolin for transurethral enucleation of the prostate in benign prostatic hyperplasia patients without pyuria or bacteriuria between January 2015 and December 2018.ResultsThis multicenter randomized controlled trial included 203 patients who underwent a transurethral enucleation of the prostate procedure. All received antimicrobial prophylaxis, and were randomized into those who received single‐dose (n= 101) or multiple‐dose (n= 102) therapy. The rate of genitourinary tract infection after transurethral enucleation of the prostate for all patients was 1.5%, whereas that in the single‐dose group was 1.0% and in the multiple‐dose group was 2.0%, which were not significantly different (P= 1.00).ConclusionsA single dose of antimicrobial prophylaxis as a prophylactic antibacterial drug is sufficient for patients undergoing transurethral enucleation of the prostate who do not have presurgical pyuria or bacteriuria.
登录
查看更多内容
影响因子：
2.6
作者：
Masumori, Naoya;Kamoto, Toshiyuki;Homma, Yukio
通讯作者：
Homma, Yukio
影响因子：
2.6
作者：
Kikuchi, Mina;Kameyama, Koji;Miwa, Kosei
通讯作者：
Miwa, Kosei
经尿道前列腺切除术中预防性使用抗生素：一项荟萃分析。
影响因子：
6.6
作者：
A. Berry;A. Barratt
通讯作者：
A. Barratt
影响因子：
0.7
作者：
Alsaywid BS;Smith GH
通讯作者：
Smith GH
影响因子：
23.4
作者：
Wagenlehner, FME;Wagenlehner, C;Naber, KG
通讯作者：
Naber, KG