SPECT imaging of the stomach: comparison with barostat, and effects of sex, age, body mass index, and fundoplication
SPECT imaging of the stomach: comparison with barostat, and effects of sex, age, body mass index, and fundoplication
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DOI：
10.1136/gut.51.6.781
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发表时间：
2002-12-01
期刊：
影响因子：
24.5
通讯作者：
Chial, HJ
中科院分区：
文献类型：
--
作者：
Bouras, EP;Delgado-Aros, S;Chial, HJ
背景：胃调节受损可能导致消化不良症状。已经开发出一种使用单光子发射计算机断层扫描（SPECT）的非侵入性方法来测量胃体积。目的和方法：我们的目的是：通过三维图像分析评估 SPECT 在体外测量球囊体积的准确性；将餐后和扩张后测量的胃恒压球囊体积与 SPECT 同时测量的胃总体积进行比较；提供健康成人的正常胃容量数据；并将健康患者的 SPECT 数据与有症状的胃底折叠术后患者的 SPECT 数据进行比较。结果：SPECT 测量的体外球囊体积非常准确（R-2=0.99）。当通过胃恒压器和SPECT同时测量时，餐后/空腹体积比（分别为2.2（0.12）（平均值（SEM））v 2.3（0.15）；p=0.6）和扩张后体积比（1.4（0.1）v1.3（0.1）；p=0.2）具有高度可比性。在女性中，通过 SPECT 测量的餐后胃容量（男性为 675 (14) vs 744 (20) ml；p=0.004）和胃容量变化（男性为 464 (14) ml vs 521 (20) ml；p=0.01）显着低于男性。没有注意到年龄或体重指数的影响。胃底折叠术后患者的餐后/空腹胃体积比 (2.7 (0.2)) 低于健康对照组 (3.4 (0.1)；p=0.003)。 结论：SPECT 提供了膳食对胃总体积影响的非侵入性估计，与用胃恒压器观察到的球囊体积变化相当。 SPECT 技术有望用于研究健康和疾病中的胃体积以及药物的作用。
Background: Impaired gastric accommodation may lead to dyspeptic symptoms. A non-invasive method using single photon emission computed tomography (SPECT) has been developed to measure gastric volumes.Aims and methods: Our aims were: to assess the accuracy of SPECT with three dimensional image analysis to measure balloon volumes in vitro; to compare gastric barostat balloon volumes measured post-meal and post-distension with total gastric volumes measured simultaneously with SPECT; to present normal gastric volume data for healthy adults; and to compare SPECT data in health with symptomatic post-fundoplication patients.Results: In vitro balloon volumes measured by SPECT were highly accurate (R-2=0.99). When measured simultaneously by gastric barostat and SPECT, postprandial/fasting volume ratios (2.2 (0.12) (mean (SEM)) v 2.3 (0.15), respectively; p=0.6) and post-distension volume ratios (1.4 (0.1) v1.3 (0.1); p=0.2) were highly comparable. In females, postprandial gastric volumes (675 (14) v 744 (20) ml for males; p=0.004) and changes in gastric volumes (464 (14) ml v 521 (20) ml for males; p=0.01) measured by SPECT were significantly lower than in males. No effects of age or body mass index were noted. The postprandial/fasting gastric volume ratio by SPECT was lower in post-fundoplication patients (2.7 (0.2)) than in healthy controls (3.4 (0.1); p=0.003).Conclusions: SPECT provides a non-invasive estimate of the effect of a meal on total gastric volume that is comparable to changes in balloon volume observed with the gastric barostat. The SPECT technique is promising for investigation of gastric volumes in health and disease and the effects of pharmacological agents.