Enantioselective synthesis of α-methyl-D-cysteine and lanthionine building blocks via α-methyl-D-serine-β-lactone
Enantioselective synthesis of α-methyl-D-cysteine and lanthionine building blocks via α-methyl-D-serine-β-lactone
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DOI：
10.1021/ol034025p
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发表时间：
2003-04-03
期刊：
影响因子：
5.2
通讯作者：
Goodman, M
中科院分区：
文献类型：
--
作者：
Smith, ND;Goodman, M
[图片]我们在这里报道了通过关键中间体boc - α -甲基- d -丝氨酸- β -内酯的重新选择开环，boc - α -甲基- d -半胱氨酸(PMB)-OH和硫代氨基酸的对映选择性合成。
[GRAPHICS]We report here the enantioselective synthesis of Boc-alpha-methyl-D-cysteine(PMB)-OH and lanthionine building blocks through the regloselective ring opening of key intermediate Boc-alpha-methyl-D-serine-beta-lactone.