Sleep wake profile and EEG spectral power in young or old senescence accelerated mice
Sleep wake profile and EEG spectral power in young or old senescence accelerated mice
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DOI：
10.1016/j.neurobiolaging.2004.03.004
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发表时间：
2005-02-01
影响因子：
4.2
通讯作者：
Sarda, N
中科院分区：
文献类型：
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作者：
Colas, D;Cespuglio, R;Sarda, N
在基线条件下或4小时睡眠剥夺（SD）后，在衰老加速易感（SAMP 8）或衰老抵抗（SAMR 1）小鼠（年龄：2和12个月）中检查皮质EEG和睡眠-觉醒状态结构随年龄发生的变化。在基线条件下，与年轻动物相比，老年SAMP 8和SAMR 1小鼠的慢波睡眠（SWS）量增加（21-24%）是以觉醒（W）为代价的。在这些条件下，SWS潜伏期减少（67-72%）。此外，在SAMP 8和SAMR 1小鼠中，衰老使反常睡眠（PS）结构恶化，SAMP 8的变化更明显（量：-63%;发作持续时间：-44%;潜伏期：+286%;昼夜节律成分损失;和EEG θ（θ）峰频率（TPF）：-1Hz）。在4小时睡眠剥夺后的4小时恢复期间，老年SAMP 8小鼠表现出增强的敏感性，导致SWS（+62%）和PS（+120%）反弹，这是该近交系的特征。所获得的结果进行了讨论，与年龄相关的学习和记忆障碍中存在的SAMP 8动物。特别是，旧SAMP 8中描述的认知性能降低可能与PS期间的TPF恶化有关。(C)2004爱思唯尔公司All rights reserved.
Changes occurring with age in cortical EEG and sleep-wake states architecture were examined in senescence accelerated prone (SAMP8) or senescence resistant (SAMR1) mice (age: 2 and 12 months) under baseline conditions or after a 4 h sleep deprivation (SD). In baseline conditions, an increase in slow wave sleep (SWS) amount (21-24%) occurs at the expense of the wakefulness (W) in old SAMP8 and SAMR1 mice versus young animals. In these conditions, SWS latency is reduced (67-72%). Moreover, in SAMP8 and SAMR1 mice, aging deteriorates paradoxical sleep (PS) architecture with more pronounced changes in SAMP8 (amount: -63%; episode duration: -44%; latency: +286%; circadian component loss; and EEG theta (theta) peak frequency (TPF): -1 Hz). During the 4 h recovery subsequent to a 4 h sleep deprivation, old SAMP8 mice exhibit an enhanced sensitivity resulting in SWS (+62%) and PS (+120%) rebounds, a characteristic of this inbred strain. Results obtained are discussed in line with the age-related learning and memory impairments existing in SAMP8 animals. In particular, the reduced cognitive performances described in old SAMP8 might be linked to the TPF deterioration during PS. (C) 2004 Elsevier Inc. All rights reserved.