To sleep or not to sleep - Effects on memory in normal aging and disease.
To sleep or not to sleep - Effects on memory in normal aging and disease.
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DOI：
10.1016/j.nbas.2023.100068
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Vetrivelan R
中科院分区：
文献类型：
--
作者：
Kroeger D;Vetrivelan R
睡眠行为在整个生命周期中会发生显着变化，衰老与睡眠量和质量的显着变化有关。健康老年人的主要睡眠变化包括睡眠时间的改变，慢波睡眠减少和睡眠维持受损。然而，神经退行性疾病和精神疾病在老年人中更常见，这进一步恶化了他们的睡眠健康。不管是什么原因，睡眠不足都会对身体的各种功能产生不利影响，包括能量代谢，情绪和认知。在这篇综述中，我们将重点关注在正常老化过程中与睡眠不足相关的认知变化及其潜在的神经机制。
Sleep behavior undergoes significant changes across the lifespan, and aging is associated with marked alterations in sleep amounts and quality. The primary sleep changes in healthy older adults include a shift in sleep timing, reduced slow-wave sleep, and impaired sleep maintenance. However, neurodegenerative and psychiatric disorders are more common among the elderly, which further worsen their sleep health. Irrespective of the cause, insufficient sleep adversely affects various bodily functions including energy metabolism, mood, and cognition. In this review, we will focus on the cognitive changes associated with inadequate sleep during normal aging and the underlying neural mechanisms.