MORPHOMETRY OF HUMAN CORONARY CAPILLARIES DURING NORMAL GROWTH AND THE EFFECT OF AGE IN LEFT-VENTRICULAR PRESSURE-OVERLOAD HYPERTROPHY
MORPHOMETRY OF HUMAN CORONARY CAPILLARIES DURING NORMAL GROWTH AND THE EFFECT OF AGE IN LEFT-VENTRICULAR PRESSURE-OVERLOAD HYPERTROPHY
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DOI：
10.1161/01.cir.86.1.38
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发表时间：
1992-07-01
期刊：
影响因子：
37.8
通讯作者：
VANPRAAGH, R
中科院分区：
文献类型：
--
作者：
RAKUSAN, K;FLANAGAN, MF;VANPRAAGH, R
背景。在成人中，获得性压力过载左心室肥厚可导致心肌缺血，其部分原因可能是肥厚发展过程中毛细血管生长不足。冠状动脉微血管对儿童先天性压力超载肥厚的反应以前没有被描述过。方法与结果。测量了63例死后左室肥厚的人心脏和无心脏病的对照心脏的平均毛细血管密度和毛细血管间距的异质性。病理标本选择1)先天性孤立性主动脉瓣狭窄引起的婴儿左心室肥厚
Background. In adults, acquired pressure-overload left ventricular hypertrophy can result in myocardial ischemia, which may be due in part to insufficient capillary growth during development of hypertrophy. The coronary microvascular response to congenital pressure-overload hypertrophy in children has not been previously characterized.Methods and Results. Average capillary density and heterogeneity of capillary spacing were measured in 63 postmortem human hearts with left ventricular hypertrophy and control hearts without heart disease. Pathology specimens were chosen that had left ventricular hypertrophy caused by 1) congenital isolated aortic valve stenosis in infants