The influence of age and gender on resting energy expenditure in severely burned children
The influence of age and gender on resting energy expenditure in severely burned children
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DOI：
10.1097/01.sla.0000217678.78472.d3
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发表时间：
2006-07-01
影响因子：
9
通讯作者：
Herndon, David N.
中科院分区：
文献类型：
--
作者：
Mlcak, Ronald P.;Jeschke, Marc G.;Herndon, David N.
简介：最近的证据表明，与男性相比，女性严重烧伤儿童的内源性合成代谢激素水平较高，ICU住院时间较短。本研究的目的是分析年龄和性别的影响石油静息能量消耗（REE）在严重烧伤的儿童从急性住院到12个月postburn.Methods：共100例小儿烧伤总体表面积（TBSA）>40%的患者参加了一项前瞻性研究，随后进行间接热量测量。REE以实际REE千卡/日、占预计REE的百分比和REE/体重指数（BMI）表示。通过Student t检验和单因素ANOVA对重复测量进行统计分析。结果：男性REE在各时间点均显著高于女性（P < 0.05）。在急性期、出院时、伤后6个月和9个月，男性REE预测值百分比显著高于女性（P < 0.05）。急性期和出院时的REE/BMI男女差异有统计学意义（P < 0.05）。在3 ~ 9.9岁儿童中，急性期、出院时和伤后6个月，男性REE测定值和REE预测值百分比均显著高于女性（P < 0.05）。结论：与男性儿童相比，女性儿童的高代谢反应明显减轻，这可能有助于改善女性儿童的烧伤预后。
Introduction: Recent evidence suggests that female severely burned children have higher endogenous anabolic hormone levels and a shorter ICU stay compared with males. The purpose of this study was to analyze the influence of age and gender oil resting energy expenditure (REE) in severely burned children from acute hospitalization through 12 months postburn.Methods: A total of 100 pediatric patients with >40% total body surface area (TBSA) burn were enrolled in a prospective study and followed by indirect calorimetry measurements. The REE was expressed as actual REE kcal/d, percent of predicted REE, and REE/ body mass index (BMI). Statistical analysis was performed by Student t test and one-way ANOVA for repeated measures. Significance was accepted at P < 0.05.Results: The measured REE was significantly higher in males versus females at all time points (P < 0.05). The percent of predicted REE was significantly higher in males versus females during the acute hospitalization, at discharge, 6 and 9 months postburn (P < 0.05). The REE/BMI showed a significant difference between males and females at the acute and discharge time period (P < 0.05). In children 3 to 9.9 years of age, the measured REE and the percent of predicted REE were significantly higher in males versus females during the acute study, at discharge and 6 months postburn (P < 0.05). The measured REE at discharge, 9 and 12 months postburn for children >10 years of age was significantly higher in males compared with females (P < 0.05).Conclusion: Data show that female children exert a decreased hypermetabolic response compared with male children, which may improve burn outcomes in females.