The aryl hydrocarbon receptor pathway and sexual differentiation of neuroendocrine functions.
The aryl hydrocarbon receptor pathway and sexual differentiation of neuroendocrine functions.
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DOI：
10.1210/en.2005-1157
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发表时间：
2006-06
期刊：
影响因子：
4.8
通讯作者：
S. Petersen;Sudha Krishnan;Edward D Hudgens
中科院分区：
文献类型：
--
作者：
S. Petersen;Sudha Krishnan;Edward D Hudgens
从历史上看，许多关于环境污染物对健康影响的研究都集中在确定化合物是否致癌。最近的研究结果表明，环境污染物也通过干扰激素作用产生潜在影响。特别令人关切的是，在动物模型中，发育过程中接触二恶英（通过芳香烃受体途径起作用的化学品）会永久改变性分化的神经功能。在这篇综述中，我们专注于二恶英破坏神经内分泌发育的机制，例如对啮齿动物排卵的关键脑区的影响。我们还提供了证据表明，GABA能神经发育失调可能是围产期二恶英暴露后广泛影响的一般机制。
Historically, much of the research on health effects of environmental pollutants focused on ascertaining whether compounds were carcinogenic. More recent findings show that environmental contaminants also exert insidious effects by disrupting hormone action. Of particular concern are findings that developmental exposure to dioxins, chemicals that act through the aryl hydrocarbon receptor pathway, permanently alters sexually differentiated neural functions in animal models. In this review, we focus on mechanisms through which dioxins disrupt neuroendocrine development as exemplified by effects on a brain region critical for ovulation in rodents. We also provide evidence that dysregulation of GABAergic neural development may be a general mechanism underlying a broad spectrum of effects seen after perinatal dioxin exposure.