A clinical, noninvasive, MR imaging monitored ultrasound surgery method
A clinical, noninvasive, MR imaging monitored ultrasound surgery method
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DOI：
10.1148/radiographics.16.1.185
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发表时间：
1996-01-01
期刊：
影响因子：
5.5
通讯作者：
Jolesz, FA
中科院分区：
文献类型：
--
作者：
Hynynen, K;Freund, WR;Jolesz, FA
已经开发了一种利用磁共振（MR）成像引导和监测的非侵入性组织消融方法。该方法使用不同焦距的尖锐聚焦超声换能器，在短时间暴露（1-20秒）期间诱导局部温度升高。液压、计算机控制的定位装置移动MR成像仪中的换能器。定位器内置于成像仪的标准支架中。该系统包括气穴检测和功率监测电路，以确保患者安全。用超声处理前即刻获得的横截面MR图像勾画靶体积。通过软件，焦点移动以消融由图像限定的体积。暴露期间的温度升高通过质子共振频移与快速梯度回波序列监测，坏死体积显示与T2加权快速自旋回波图像。这种方法已经在体内动物实验中进行了广泛的测试，目前正在进行临床试验。
A noninvasive method of tissue ablation that is guided and monitored with magnetic resonance (MR) imaging has been developed. The method uses sharply focused ultrasound transducers of different focal lengths to induce a localized temperature elevation during a short exposure (1-20 seconds). A hydraulic, computer-controlled positioning device moves the transducer in an MR imager. The positioner is built into a standard cradle in the imager. The system includes cavitation detection and power monitoring circuitry for patient safety. The target volume is outlined with cross-sectional MR images obtained immediately before sonication. By means of the software, the focus is moved to ablate the volume defined with the images. The temperature elevation during the exposure is monitored by means of the proton resonance frequency shift with fast gradient-echo sequences, and the necrosed volume is demonstrated with T2-weighted fast spin-echo images. This method has been extensively tested in in vivo animal experiments and is now undergoing clinical trial.