Effect of synaptic connectivity on long-range synchronization of fast cortical oscillations
Effect of synaptic connectivity on long-range synchronization of fast cortical oscillations
复制标题
DOI：
10.1152/jn.90613.2008
复制
发表时间：
2008-09-01
影响因子：
2.5
通讯作者：
Timofeev, I.
中科院分区：
文献类型：
--
作者：
Bazhenov, M.;Rulkov, N. F.;Timofeev, I.
20 至 80 Hz 范围内的皮质伽马振荡与注意力和感官知觉相关，并且与认知处理和感官刺激的时间结合有很强的联系。尽管存在突触延迟，这些伽马振荡在几毫秒内就在几毫米的距离内变得同步。在这项使用体内记录和大规模皮层网络模型的研究中，我们揭示了网络几何结构在伽马频带实现精确远程同步中所发挥的关键作用。我们的结果表明，二维网络中存在许多独立的突触路径，有利于快速伽马带振荡的精确相位同步，远程网络站点之间的相位延迟几乎为零。这些发现预测了神经元网络中精确振荡同步的常见机制。
Cortical gamma oscillations in the 20- to 80-Hz range are associated with attentiveness and sensory perception and have strong connections to both cognitive processing and temporal binding of sensory stimuli. These gamma oscillations become synchronized within a few milliseconds over distances spanning a few millimeters in spite of synaptic delays. In this study using in vivo recordings and large-scale cortical network models, we reveal a critical role played by the network geometry in achieving precise long-range synchronization in the gamma frequency band. Our results indicate that the presence of many independent synaptic pathways in a two-dimensional network facilitate precise phase synchronization of fast gamma band oscillations with nearly zero phase delays between remote network sites. These findings predict a common mechanism of precise oscillatory synchronization in neuronal networks.