Amygdala activity for the modulation of goal-directed behavior in emotional contexts
Amygdala activity for the modulation of goal-directed behavior in emotional contexts
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DOI：
10.1371/journal.pbio.2005339
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发表时间：
2018-06-01
期刊：
影响因子：
9.8
通讯作者：
Hikosaka, Okihide
中科院分区：
文献类型：
--
作者：
Maeda, Kazutaka;Kunimatsu, Jun;Hikosaka, Okihide
选择有价值的物品和奖励行为对于生存至关重要。虽然这种选择必须以适合动物环境的方式做出，但这种适应环境的行为背后的神经机制尚不清楚。为了解决这个问题，我们为猕猴设计了一个依赖于环境的奖励寻求任务。每次试验都是从包含两个或多个物体的多个视觉场景之一开始，猴子必须通过扫视选择好的物体才能获得奖励。这些场景被分为情感背景的两个维度：危险与安全、富裕与贫穷。我们发现，许多杏仁核神经元在危险场景、丰富场景或两者兼有时被更强烈地激活。此外，在危险场景中，对目标物体的扫视发生得比在安全场景中更快，在富裕场景中也比在贫困场景中更快。因此，每只猴子的杏仁核神经元活动和扫视反应时间呈负相关。这些结果表明，杏仁核神经元有助于根据情绪背景的各个方面进行可预测的目标扫视，这对于目标导向和社交行为是必要的。
Choosing valuable objects and rewarding actions is critical for survival. While such choices must be made in a way that suits the animal's circumstances, the neural mechanisms underlying such context-appropriate behavior are unclear. To address this question, we devised a context-dependent reward-seeking task for macaque monkeys. Each trial started with the appearance of one of many visual scenes containing two or more objects, and the monkey had to choose the good object by saccade to get a reward. These scenes were categorized into two dimensions of emotional context: dangerous versus safe and rich versus poor. We found that many amygdala neurons were more strongly activated by dangerous scenes, by rich scenes, or by both. Furthermore, saccades to target objects occurred more quickly in dangerous than in safe scenes and were also quicker in rich than in poor scenes. Thus, amygdala neuronal activity and saccadic reaction times were negatively correlated in each monkey. These results suggest that amygdala neurons facilitate targeting saccades predictably based on aspects of emotional context, as is necessary for goal-directed and social behavior.