Endothelial SARS-CoV-2 infection is not the underlying cause of COVID-19-associated vascular pathology in mice.
Endothelial SARS-CoV-2 infection is not the underlying cause of COVID-19-associated vascular pathology in mice.
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DOI：
10.3389/fcvm.2023.1266276
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发表时间：
2023
影响因子：
3.6
通讯作者：
Kahn ML
中科院分区：
文献类型：
--
作者：
Gao S;Tang AT;Wang M;Buchholz DW;Imbiakha B;Yang J;Chen X;Hewins P;Mericko-Ishizuka P;Leu NA;Sterling S;August A;Jurado KA;Morrisey EE;Aguilar-Carreno H;Kahn ML
自疫情开始以来，内皮损伤和血管病理一直被认为是新冠肺炎的主要特征。关于严重急性呼吸综合征冠状病毒2(SARS-CoV-2)损伤内皮细胞和引起血管病变的主要理论有两种：一种是病毒直接感染内皮细胞，另一种是由循环炎症分子和免疫机制介导的间接损伤。然而，这些拟议的机制在很大程度上仍未在体内进行测试。在本研究中，我们利用我们实验室开发的一套新的小鼠基因工具来检测内皮组织人血管紧张素转换酶2在新冠肺炎发病中的必要性和充分性。我们的结果表明，血管内皮细胞血管紧张素转换酶2和血管内皮细胞的直接感染在新冠肺炎相关的多种血管病变中没有显著的贡献。
Endothelial damage and vascular pathology have been recognized as major features of COVID-19 since the beginning of the pandemic. Two main theories regarding how severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) damages endothelial cells and causes vascular pathology have been proposed: direct viral infection of endothelial cells or indirect damage mediated by circulating inflammatory molecules and immune mechanisms. However, these proposed mechanisms remain largely untested in vivo. In the present study, we utilized a set of new mouse genetic tools developed in our lab to test both the necessity and sufficiency of endothelial human angiotensin-converting enzyme 2 (hACE2) in COVID-19 pathogenesis. Our results demonstrate that endothelial ACE2 and direct infection of vascular endothelial cells do not contribute significantly to the diverse vascular pathology associated with COVID-19.
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影响因子：
9.8
作者：
Smadja DM;Mentzer SJ;Fontenay M;Laffan MA;Ackermann M;Helms J;Jonigk D;Chocron R;Pier GB;Gendron N;Pons S;Diehl JL;Margadant C;Guerin C;Huijbers EJM;Philippe A;Chapuis N;Nowak-Sliwinska P;Karagiannidis C;Sanchez O;Kümpers P;Skurnik D;Randi AM;Griffioen AW
通讯作者：
Griffioen AW
影响因子：
64.8
作者：
Delorey TM;Ziegler CGK;Heimberg G;Normand R;Yang Y;Segerstolpe Å;Abbondanza D;Fleming SJ;Subramanian A;Montoro DT;Jagadeesh KA;Dey KK;Sen P;Slyper M;Pita-Juárez YH;Phillips D;Biermann J;Bloom-Ackermann Z;Barkas N;Ganna A;Gomez J;Melms JC;Katsyv I;Normandin E;Naderi P;Popov YV;Raju SS;Niezen S;Tsai LT;Siddle KJ;Sud M;Tran VM;Vellarikkal SK;Wang Y;Amir-Zilberstein L;Atri DS;Beechem J;Brook OR;Chen J;Divakar P;Dorceus P;Engreitz JM;Essene A;Fitzgerald DM;Fropf R;Gazal S;Gould J;Grzyb J;Harvey T;Hecht J;Hether T;Jané-Valbuena J;Leney-Greene M;Ma H;McCabe C;McLoughlin DE;Miller EM;Muus C;Niemi M;Padera R;Pan L;Pant D;Pe'er C;Pfiffner-Borges J;Pinto CJ;Plaisted J;Reeves J;Ross M;Rudy M;Rueckert EH;Siciliano M;Sturm A;Todres E;Waghray A;Warren S;Zhang S;Zollinger DR;Cosimi L;Gupta RM;Hacohen N;Hibshoosh H;Hide W;Price AL;Rajagopal J;Tata PR;Riedel S;Szabo G;Tickle TL;Ellinor PT;Hung D;Sabeti PC;Novak R;Rogers R;Ingber DE;Jiang ZG;Juric D;Babadi M;Farhi SL;Izar B;Stone JR;Vlachos IS;Solomon IH;Ashenberg O;Porter CBM;Li B;Shalek AK;Villani AC;Rozenblatt-Rosen O;Regev A
通讯作者：
Regev A
影响因子：
168.9
作者：
Huang, Chaolin;Wang, Yeming;Cao, Bin
通讯作者：
Cao, Bin
影响因子：
158.5
作者：
Ackermann, Maximilian;Verleden, Stijn E.;Jonigk, Danny
通讯作者：
Jonigk, Danny
影响因子：
5.8
作者：
Schimmel L;Chew KY;Stocks CJ;Yordanov TE;Essebier P;Kulasinghe A;Monkman J;Dos Santos Miggiolaro AFR;Cooper C;de Noronha L;Schroder K;Lagendijk AK;Labzin LI;Short KR;Gordon EJ
通讯作者：
Gordon EJ