BILIARY ATRESIA AND REOVIRUS TYPE-3 INFECTION
BILIARY ATRESIA AND REOVIRUS TYPE-3 INFECTION
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DOI：
10.1056/nejm198208193070806
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发表时间：
1982-01-01
影响因子：
158.5
通讯作者：
HORWITZ, MS
中科院分区：
文献类型：
--
作者：
MORECKI, R;GLASER, JH;HORWITZ, MS
新生儿胆道闭锁最初被认为是一种发育畸形。然而，在门静脉肠造口术中切除的胆管的显微镜检查显示炎症病变，提示正在进行的产后过程，如感染。1,2病毒分离和血清学研究通常为阴性，除了偶尔与巨细胞病毒或先天性风疹感染相关的病例。我们对呼肠孤病毒3型（reo-3）作为胆道闭锁的潜在原因的兴趣是由Stanley等人的观察引起的。他们描述了小鼠慢性阻塞性黄疸，与断奶动物腹腔注射reo-3后胆道闭塞有关。虽然肝损伤是……
NEONATAL biliary atresia was originally thought to be a developmental malformation. However, microscopical examination of bile ducts resected during portoenterostomy has revealed inflammatory lesions suggesting an ongoing postnatal process such as infection.1,2Viral isolation and serologic studies have usually been negative except for an occasional case associated with cytomegalovirus or congenital rubella infection.3456Our interest in reovirus type 3 (reo-3) as a potential cause of biliary atresia was stimulated by the observations of Stanley et al.7They described chronic obstructive jaundice in mice, associated with choledochal obliteration that followed intraperitoneal injection of reo-3 into weanling animals.8Although hepatic injury is . . .