Solar cheilosis: An ominous precursor Part I. Diagnostic insights
Solar cheilosis: An ominous precursor Part I. Diagnostic insights
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DOI：
10.1016/j.jaad.2011.09.040
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发表时间：
2012-02-01
影响因子：
13.8
通讯作者：
Schwartz, Robert A.
中科院分区：
文献类型：
--
作者：
Jadotte, Yuri T.;Schwartz, Robert A.
下唇鳞状细胞癌（SCC）是一种致命的非黑色素瘤皮肤癌。它的前体是一种独特的皮肤肿瘤，类似于宫颈发育不良，被称为光化性唇炎。太阳cheilosis （SC）是一个更合适的名称。它代表原位的早期SCC。SC被广泛认为是一种紫外线诱发的下唇癌前病变，通常见于肤色浅的人和其他下唇色素不足的人。唇部鳞状细胞癌是口腔最常见的恶性肿瘤之一。SCC更容易从唇部转移，而不是皮肤表面，5年总生存率低于75%。SC是由于长期暴露于紫外线辐射造成的。SC的发生是剂量依赖性的，受患者日晒、年龄、遗传易感性、居住地地理纬度、职业、休闲活动和唇部保护剂使用的影响。SC的分子异常与光化性角化病相似，有利于SCC的发展。鉴于这种疾病的恶性性质，应保持高度的临床怀疑。溃疡和结节通常表明SCC的进展。我们在Medline和谷歌Scholar上检索了所有与光化性口疮、光化性口疮、SC、光化性角化病、太阳角化病、癌前口腔疾病和唇部SCC相关的文章，并对许多其他文章和书籍章节进行了评估。142篇同行评议的文章被确定为具有特殊价值。选取并分析了相关事实。[J] .中华皮肤科杂志，2012;66:173-84。]
Squamous cell carcinoma (SCC) of the lower lip is a deadly nonmelanoma skin cancer. Its precursor, a distinctive cutaneous neoplasia analogous to cervical dysplasia, is known by the confusing term actinic cheilitis. Solar cheilosis (SC) is a more appropriate designation. It represents incipient SCC in situ. SC is widely recognized as an ultraviolet light induced precancer of the lower lip that is typically seen in light-skinned individuals and others with poorly pigmented lower lips. Lip SCC is one of the most common malignancies of the oral cavity. SCC is much more likely to metastasize from the lip than cutaneous surfaces, with a 5-year overall survival rate of less than 75%. SC results from long-term exposure to ultraviolet radiation. The occurrence of SC is dose-dependent and is influenced by the patient's solar exposure, age, genetic predisposition, geographic latitude of residence, occupation, leisure activities, and use of lip protective agents. Molecular abnormalities of SC are similar to those of actinic keratosis and facilitate the evolution to SCC. A high degree of clinical suspicion should be maintained, given the malignant nature of this condition. Ulceration and nodularity often indicate progression to SCC. We performed a Medline and Google Scholar search for all articles related to actinic cheilitis, actinic cheilosis, SC, actinic keratosis, solar keratosis, premalignant oral disease, and lip SCC, and have also evaluated many other articles and book chapters. One hundred forty-two peer-reviewed articles were identified as being of particular value. Pertinent facts were selected and analyzed. (J Am Acad Dermatol 2012;66:173-84.)