ARTICULAR-CARTILAGE PROTEOGLYCANS IN AGING AND OSTEOARTHRITIS
ARTICULAR-CARTILAGE PROTEOGLYCANS IN AGING AND OSTEOARTHRITIS
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DOI：
10.1042/bj1690143
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发表时间：
1978-01-01
影响因子：
4.1
通讯作者：
OLSSON, SE
中科院分区：
文献类型：
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作者：
INEROT, S;HEINEGARD, D;OLSSON, SE
研究了从不同年龄的狗获得的宏观正常髋关节软骨的成分。对有退化迹象的软骨片进行了单独研究。正常老化时，蛋白多糖的提取率下降；提取的蛋白多糖中硫酸角质素含量增加，硫酸软骨素含量减少。在较老的软骨中提取的蛋白多糖较小，这主要是由于蛋白多糖单体中富含硫酸软骨素的区域减少。随着年龄的增长，透明质酸结合区和富含硫酸角质素的区域增加，并且蛋白多糖的摩尔浓度可能增加。退化的软骨具有更高的含水量，并且蛋白聚糖以及其他组织成分的产量更高。退变软骨的蛋白多糖单体比同龄正常软骨的蛋白多糖单体小，因此富含硫酸软骨素的区域也较小，并且一些分子似乎缺乏透明质酸结合区域。蛋白水解活性增加可能参与软骨退化过程。
The composition of macroscopically normal hip articular cartilage obtained from dogs of various ages was studied. Pieces of cartilage with signs of degeneration were studied separately. In normal aging the extraction yield of proteoglycans decreased; the keratan sulfate content of extracted proteoglycans increased, and the chondroitin sulfate content decreased. The extracted proteoglycans were smaller in the older cartilage, mainly owing to a decrease in the chondroitin sulfate-rich region of the proteoglycan monomers. The hyaluronic acid-binding region and the keratan sulfate-rich region were increased and the molar concentration of proteoglycan probably increased with increasing age. The degenerated cartilage had higher water content, and the proteoglycans, as well as other tissue components, gave higher yields. The proteoglycan monomers from the degenerated cartilage were smaller than those from normal cartilage of the same age, and hence had a smaller chondroitin sulfate-rich region, and some of the molecules appeared to lack the hyaluronic acid-binding region. Increased proteolytic activity may be involved in the process of cartilage degeneration.