A new copper acetate-bis(oxazoline)-catalyzed, enantioselective Henry reaction
A new copper acetate-bis(oxazoline)-catalyzed, enantioselective Henry reaction
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DOI：
10.1021/ja0373871
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发表时间：
2003-10-22
影响因子：
15
通讯作者：
Downey, CW
中科院分区：
文献类型：
--
作者：
Evans, DA;Seidel, D;Downey, CW
研究了手性Cu（II）双恶唑啉配合物催化的高对映选择性硝基羟醛缩合反应。反应范围包括芳族和脂族醛（15个实例），以良好的产率和对映选择性（87 - 94%ee）提供产物。沿着提供了催化剂的X射线结构，并对不对称诱导的意义进行了合理化。
A highly enantioselective, nitroaldol reaction catalyzed by a chiral Cu(II) bis(oxazoline) complex has been developed. The reaction scope includes both aromatic and aliphatic aldehydes (15 examples) affording products in good yields and enantioselectivities (87−94% ee). An X-ray structure of the catalyst has been provided along with a rationalization of the sense of asymmetric induction.