Effect of six steroidal saponins isolated from anemarrhenae rhizoma on platelet aggregation and hemolysis in human blood
Effect of six steroidal saponins isolated from anemarrhenae rhizoma on platelet aggregation and hemolysis in human blood
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DOI：
10.1016/s0009-8981(99)00160-6
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发表时间：
1999-11-01
影响因子：
5
通讯作者：
Kodama, H
中科院分区：
文献类型：
--
作者：
Zhang, JY;Meng, ZY;Kodama, H
从中药知母中分离得到 6 种甾体皂苷，分别命名为知母皂苷 I (An-I)、知母皂苷 Ia (An-Ia)、知母皂苷 B-I (TB-I)、知母皂苷 B-II (TB-LT)、知母皂苷 B-III (TB-UI) 和知母皂苷 A-Iii （TA-III）。研究了这六种化合物对人体血液中血小板聚集和溶血的影响。所有这些化合物均对血小板聚集产生显着的抑制作用，并且活化部分凝血活酶时间（APTT）对这六种化合物的存在敏感。使用体外系统，APTT 随着这六种化合物浓度的增加而延迟。这6种化合物中，只有知母皂苷A-III有较强的溶血作用，知母皂苷Ia有轻微的溶血作用，其他化合物均无溶血作用。这些结果表明，从知母（百合科）中分离的甾体皂苷可用作心肌梗塞后的新型抗血栓治疗剂。 (C) 1999 Elsevier Science B.V. 保留所有权利。
Six steroidal saponins were isolated from Anemarrhena asphodeloides Bunge (Liliaceae), a traditional chinese medicine, and named anemarrhenasaponin I (An-I), anemarrhenasaponin Ia (An-Ia), timosaponin B-I (TB-I), timosaponin B-II (TB-LT), timosaponin B-III (TB-UI), and timosaponin A-Iii (TA-III). The effects of these six compounds on platelet aggregation and hemolysis in human blood were studied. All these compounds provoked remarkable inhibiting effect on platelet aggregation, and activated partial thromboplastin times (APTT) are sensitive to the presence of these six compounds. Using an in vitro system, APTT was delayed with the increment of the concentrations of these six compounds. In these six compounds, only timosaponin A-III appeared a strong effect on hemolysis, and anemarrhenasaponin Ia had a slight effect on hemolysis, other had no effect on hemolysis. These results suggested that these steroidal saponins isolated from Anemarrhena asphodeloides Bunge (Liliaceae) might be used as a novel antithrombotic therapeutic agents in post-myocardial infarction. (C) 1999 Elsevier Science B.V. All rights reserved.