Placental transfer and maternally acquired neonatal IgG immunity in human immunodeficiency virus infection
Placental transfer and maternally acquired neonatal IgG immunity in human immunodeficiency virus infection
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DOI：
10.1093/infdis/173.5.1077
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发表时间：
1996-05-01
影响因子：
6.4
通讯作者：
Hart, CA
中科院分区：
文献类型：
--
作者：
deMoraesPinto, MI;Almeida, ACM;Hart, CA
本文对46对HIV-1阳性孕妇及其新生儿和53对HIV阴性孕妇及其新生儿进行了特异性IgG抗体经胎盘转移的研究。用比浊法测定新生儿和孕妇血清中IgG总水平，用ELISA法测定单纯疱疹病毒（HSV）、水痘-带状疱疹病毒（VZV）、麻疹病毒（MV）、破伤风环状体、链球菌溶血素O和肺炎链球菌荚膜抗原。VZV、破伤风、麻疹、链球菌溶血素O和S的IgG抗体的胎盘转移。母亲血清总IgG水平对HSV、VZV、麻疹和S.肺炎。新生儿破伤风、麻疹和沙门氏菌抗体水平。HIV感染者中，母亲高丙种球蛋白血症和母亲HIV感染均可能导致出生时抗体水平低，从而导致该高危人群的早期感染。
Transplacental transfer of specific IgG antibodies was studied in 46 pairs of human immunodeficiency virus type 1 (HIV-1)-seropositive women and their neonates and in 53 pairs of healthy HIV-seronegative mothers and their newborns, Neonatal and maternal sera were assessed by nephelometry for total levels of serum IgG and by ELISA for IgG antibodies to herpes simplex virus (HSV), varicella-zoster virus (VZV), measles virus, tetanus toroid, streptolysin O, and Streptococcus pneumoniae capsular antigens. Placental transfer of IgG antibodies to VZV, tetanus toroid, measles, streptolysin O, and S. pneumoniae was decreased by maternal HIV infection, Maternal levels of total IgG had an independent effect on transfer of antibodies to HSV, VZV, measles, and S. pneumoniae. Neonatal antibody levels to tetanus toroid, measles, and S. pneumoniae were significantly lower in the HIV group, Both maternal hypergammaglobulinemia and maternal HIV infection may contribute to these low antibody levels at birth and thus lead to early infection in this high-risk population.