Comparison of two blood pool contrast agents for 0.5-T MR angiography: Experimental study in rabbits
Comparison of two blood pool contrast agents for 0.5-T MR angiography: Experimental study in rabbits
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DOI：
10.1148/radiology.214.3.r00mr25787
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发表时间：
2000-03-01
期刊：
影响因子：
19.7
通讯作者：
Rutt, BK
中科院分区：
文献类型：
--
作者：
Clarke, SE;Weinmann, HJ;Rutt, BK
目的：评价两种实验性血池造影剂在平衡期腹部磁共振(MR)血管成像中的应用。材料和方法：37只兔在0.5T条件下进行MR成像，分别在静脉注射含Gd的血池造影剂(SH L 643A)、超顺磁性氧化铁血池造影剂(SH U 555C)或加多巴喷妥钠地葡胺后进行。获得了从肾动脉到髂骨分叉下方的T1加权快速破坏梯度回波图像。结果：两种血池显像剂均能很好地显示兔腹主动脉。在0.1mmo1/kg剂量下，两者的主动脉-组织柔红度均显著高于加多喷妥组(SH L 643A增加200%，SH U 555C；P<；0.05增加95%)。0.1mmoL/kg剂量的SH L 643A使SDNR增加24%，而0.37mmoL/kg剂量的加多喷妥钠地葡胺则增加24%。由于消除方法的不同，血池造影剂的时间依赖性增强特性也不同。结论：两种血池造影剂都是很有前途的0.5-T磁共振血管成像对比剂，但其临床适用性值得进一步研究。与氧化铁化合物相比，基于Gd的试剂具有几个优点，包括较少的T2*脱相，没有易感性伪影，以及快速的肾脏消除。
PURPOSE: To evaluate two experimental blood pool agents for potential use in equilibrium phase abdominal magnetic resonance (MR) angiography.MATERIALS AND METHODS: MR imaging at 0.5 T was performed in 37 rabbits before and after intravenous injection of a gadolinium-based blood pool contrast agent (SH L 643 A), superparamagnetic iron oxide blood pool agent (SH U 555 C), or gadopentetate dimeglumine. T1-weighted fast spoiled gradient-echo images from the renal arteries to below the iliac bifurcation were obtained. The aorta-to-tissue signal difference-to-noise ratio (SDNR) was measured over time.RESULTS: Both blood pool agents yielded excellent demonstration of the rabbit abdominal aorta. At a dose of 0.1 mmol/kg, both provided a statistically significant increase in aorta-to-tissue DNR in comparison with that achieved with gadopentetate dimeglumine (200% increase for SH L 643 A, 95% increase for SH U 555 C; P < .05). A 0.1 mmol/kg dose of SH L 643 A provided a 24% increase in SDNR relative to the increase with a 0.37 mmol/kg dose of gadopentetate dimeglumine. Time-dependent enhancement properties of the blood pool agents differed due to differences in elimination method.CONCLUSION: Both blood pool agents were found to be promising contrast agents for 0.5-T MR angiography; however, their clinical applicability warrants further investigation. The gadolinium-based agent had several advantages over the iron oxide compound, including less T2* dephasing, lack of susceptibility artifacts, and fast renal elimination.