DYNAMIC INCREMENTAL CT - EFFECT OF VOLUME AND CONCENTRATION OF CONTRAST MATERIAL AND PATIENT WEIGHT ON HEPATIC ENHANCEMENT
DYNAMIC INCREMENTAL CT - EFFECT OF VOLUME AND CONCENTRATION OF CONTRAST MATERIAL AND PATIENT WEIGHT ON HEPATIC ENHANCEMENT
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DOI：
10.1148/radiology.195.2.7724752
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发表时间：
1995-05-01
期刊：
影响因子：
19.7
通讯作者：
GAINES, MV
中科院分区：
文献类型：
--
作者：
HEIKEN, JP;BRINK, JA;GAINES, MV
目得：开发一种个体化的方法静脉注射造影剂的肝脏计算机断层扫描（CT）。材料和方法：200例患者被随机分为8个协议。每组接受不同体积和浓度的造影剂。对于每个协议，计算最大肝脏增强（MHE），调整碘剂量和患者体重。对比增强指数（CEI）和最佳扫描间隔计算肝脏增强阈值为10-60 HU。结果：作为患者体重的函数计算的MHE为96 HU +/- 19/g碘/kg体重。使用造影剂浓度为240 mg/mL碘获得的CEI劣于使用浓度为320或350 mg I/mL获得的CEI。在低增强阈值，造影剂的体积有一个更重要的效果比浓度CEI和最佳扫描间隔;在高阈值，浓度有一个更重要的effect.CONCLUSION：对于一个病人的已知重量，可以计算碘剂量需要提供一个理想的肝脏增强水平。不建议在动态增量肝脏CT中使用浓度为240 mg I/mL的造影剂，除非是体型较小的患者（例如，体重小于73 kg的患者）。
PURPOSE: To develop an individualized approach to the intravenous administration of contrast material for hepatic computed tomography (CT).MATERIALS AND METHODS: Two hundred patients were randomized into eight protocols. Each group received different volumes and concentrations of contrast material. For each protocol, maximum hepatic enhancement (MHE) was calculated, with an adjustment for iodine dose and patient weight The contrast enhancement index (CEI) and optimum scanning interval were calculated for hepatic enhancement thresholds of 10-60 HU.RESULTS: The MHE calculated as a function of patient weight was 96 HU +/- 19 per gram of iodine per kilogram of body weight. CEIs obtained with a contrast material concentration of 240 mg of iodine per milliliter were inferior to those obtained with a concentration of 320 or 350 mg I/mL. At low enhancement thresholds, the volume of contrast material had a more important effect than the concentration on CEI and optimum scanning interval; at high thresholds, concentration had a more important effect.CONCLUSION: For a patient of known weight, one can calculate the iodine dose needed to provide a desired level of hepatic enhancement. Use of a contrast material with a concentration of 240 mg I/mL is not recommended for dynamic incremental hepatic CT, except in small patients (eg, those weighing less than 73 kg).