Visual Familiarity Induced 5-Hz Oscillations and Improved Orientation and Direction Selectivities in V1.
Visual Familiarity Induced 5-Hz Oscillations and Improved Orientation and Direction Selectivities in V1.
复制标题
视觉熟悉性在V1诱发5-HZ振荡，并改善方向和方向选择性。
DOI：
10.1523/jneurosci.1337-20.2021
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发表时间：
2021-03-24
期刊：
影响因子：
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通讯作者：
Chubykin AA
中科院分区：
文献类型：
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作者：
Gao M;Lim S;Chubykin AA
神经振荡在信息处理、大脑区域之间的通信、学习和记忆中起着关键作用。我们最近发现，熟悉的视觉刺激可以鲁棒地诱导5-Hz振荡的初级视觉皮层（V1）清醒的小鼠视觉体验后。为了更深入地了解这种现象，我们使用了在体膜片钳记录来监测这些振荡过程中单个神经元的阈下活动。神经振荡在信息处理、大脑区域之间的通信、学习和记忆中起着关键作用。我们最近发现，熟悉的视觉刺激可以鲁棒地诱导5-Hz振荡的初级视觉皮层（V1）清醒的小鼠视觉体验后。为了更深入地了解这种现象，我们使用了在体膜片钳记录来监测这些振荡过程中单个神经元的阈下活动。我们分析了幼稚和有经验的小鼠V1神经元的视觉调谐特性，以评估视觉经验对定向和方向选择性的影响。使用光遗传学刺激通过在体内的贴片吸管，我们测量了特定的皮质内和丘脑皮质投射在体内的视觉皮层的突触强度之前和之后的视觉体验。我们发现5 Hz的振荡膜电位（Vm）和放电率诱发单个神经元在响应熟悉的刺激，与以前的研究一致。视觉体验后，视觉反应的平均放电率降低，而方向和方向选择性增加。视觉体验后，光诱发的EPSC的第5层（L5）的其他层的V1的投射显着增加，而丘脑皮质突触强度下降。此外，我们开发了一个计算模型，可以重现5 Hz的振荡与增强神经元的选择性突触可塑性内的递归网络和减少前馈输入。5 Hz左右的神经振荡参与初级视皮层（V1）的视觉工作记忆和时间预期。然而，振荡如何调节V1神经元的视觉反应特性及其潜在机制知之甚少。在这里，我们表明，这些振荡可能会改变2/3（L2/3）层神经元的取向和方向选择性，并与V1内的突触可塑性。我们的计算递归网络模型再现了所有这些观察，并提供了一个机械框架，研究5赫兹振荡的视觉熟悉的作用。
Neural oscillations play critical roles in information processing, communication between brain areas, learning, and memory. We have recently discovered that familiar visual stimuli can robustly induce 5-Hz oscillations in the primary visual cortex (V1) of awake mice after the visual experience. To gain more mechanistic insight into this phenomenon, we used in vivo patch-clamp recordings to monitor the subthreshold activity of individual neurons during these oscillations. Neural oscillations play critical roles in information processing, communication between brain areas, learning, and memory. We have recently discovered that familiar visual stimuli can robustly induce 5-Hz oscillations in the primary visual cortex (V1) of awake mice after the visual experience. To gain more mechanistic insight into this phenomenon, we used in vivo patch-clamp recordings to monitor the subthreshold activity of individual neurons during these oscillations. We analyzed the visual tuning properties of V1 neurons in naive and experienced mice to assess the effect of visual experience on the orientation and direction selectivity. Using optogenetic stimulation through the patch pipette in vivo, we measured the synaptic strength of specific intracortical and thalamocortical projections in vivo in the visual cortex before and after the visual experience. We found 5-Hz oscillations in membrane potential (Vm) and firing rates evoked in single neurons in response to the familiar stimulus, consistent with previous studies. Following the visual experience, the average firing rates of visual responses were reduced while the orientation and direction selectivities were increased. Light-evoked EPSCs were significantly increased for layer 5 (L5) projections to other layers of V1 after the visual experience, while the thalamocortical synaptic strength was decreased. In addition, we developed a computational model that could reproduce 5-Hz oscillations with enhanced neuronal selectivity following synaptic plasticity within the recurrent network and decreased feedforward input. SIGNIFICANCE STATEMENT Neural oscillations at around 5 Hz are involved in visual working memory and temporal expectations in primary visual cortex (V1). However, how the oscillations modulate the visual response properties of neurons in V1 and their underlying mechanism is poorly understood. Here, we show that these oscillations may alter the orientation and direction selectivity of the layer 2/3 (L2/3) neurons and correlate with the synaptic plasticity within V1. Our computational recurrent network model reproduces all these observations and provides a mechanistic framework for studying the role of 5-Hz oscillations in visual familiarity.