Effects of Obstetric Complications on Volume and Functional Connectivity of Striatum in Anorexia Nervosa Patients
Effects of Obstetric Complications on Volume and Functional Connectivity of Striatum in Anorexia Nervosa Patients
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DOI：
10.1002/eat.22320
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发表时间：
2014-11-01
影响因子：
5.5
通讯作者：
Santonastaso, Paolo
中科院分区：
文献类型：
--
作者：
Favaro, Angela;Tenconi, Elena;Santonastaso, Paolo
目的：探讨厌食症神经背侧和腹侧纹状体核的体积、功能连通性及其与产科并发症早期暴露的关系。方法：51例终身AN患者（急性期35例，康复期16例）和34例健康对照进行高分辨率和静息状态功能磁共振成像。结果：与健康女性相比，AN组壳核功能连通性降低，这种降低在终生暴饮暴食/排便的患者中更为明显。与健康女性相比，急性AN组和恢复AN组的左侧伏隔核面积都更大。AN组双侧伏隔核和壳核功能连通性与产科并发症数量呈显著负相关。讨论：本研究支持AN与纹状体网络结构和功能改变有关的假设，并揭示了产科并发症在纹状体功能障碍发病机制中的可能作用。(C) 2014 Wiley期刊公司
Objective: To investigate the volume and functional connectivity of dorsal and ventral striatal nuclei in anorexia nervosa (AN) and their relationship with early exposure to obstetric complications.Method: Fifty-one patients with lifetime AN (35 acute, 16 recovered) and 34 healthy controls underwent high-resolution and resting-state functional magnetic resonance imaging.Results: The AN group showed reduced functional connectivity of the putamen compared with healthy women, and this reduction was more evident in patients with lifetime binge eating/purging. Both acute and recovered AN groups showed a larger left accumbens area compared with that of healthy women. The functional connectivity of bilateral nucleus accumbens and putamen showed significant negative correlations with number of obstetric complications in the AN group.Discussion: This study supports the hypothesis that AN is associated with structural and functional alterations of striatal networks, and reveals the possible role of obstetric complications in the pathogenesis of striatal dysfunction. (C) 2014 Wiley Periodicals, Inc.