Electrocardiogram Changes and Therapeutic Desipramine and 2-Hydroxy-Desipramine Concentrations in Elderly Depressives
Electrocardiogram Changes and Therapeutic Desipramine and 2-Hydroxy-Desipramine Concentrations in Elderly Depressives
复制标题
老年抑郁症患者的心电图变化以及地昔帕明和 2-羟基-地昔帕明的治疗浓度
DOI：
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发表时间：
1986
影响因子：
10.5
通讯作者：
K. Shulman
中科院分区：
文献类型：
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作者：
S. Kutcher;K. Reid;J. Dubbin;K. Shulman
在常规地斯帕明治疗期间评估老年抑郁症住院患者的心电图参数。发现了显着的变化（PR 和 PRS 间期延长以及 QTc 间期缩短），仅与地昔帕明主要代谢物 2-羟基-地昔帕明的稳态浓度有关。 40% 的患者出现了潜在的临床显着变化。所有血清药物浓度均在治疗限度内。之前关于地螺旋明对老年人的心脏安全性的保证可能需要重新评估。
ECG parameters in elderly depressed in-patients were assessed during routine despramine treatment. Significant changes (prolonged PR and PRS intervals and a decreased QTc interval) were found, related only to steady state concentrations of desipramine's major metabolite—2-hydroxy-desipramine. Potentially clinically significant changes developed in 40% of the patients. All serum drug concentrations were within therapeutic limits. Previous assurances about despiramines's cardiac safety in the elderly may need to be re-evaluated.
地昔帕明血浆浓度和抗抑郁反应。
影响因子：
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作者：
Nelson,JC;Jatlow,P;Quinlan,DM;BowersJr,MB
通讯作者：
BowersJr,MB