Heritability of leptin levels and the shared genetic effects on body mass index and leptin in adult Finnish twins
Heritability of leptin levels and the shared genetic effects on body mass index and leptin in adult Finnish twins
复制标题
DOI：
10.1038/sj.ijo.0801526
复制
发表时间：
2001-01-01
影响因子：
4.9
通讯作者：
Tuomilehto, J
中科院分区：
文献类型：
--
作者：
Kaprio, J;Eriksson, J;Tuomilehto, J
目的：瘦素参与体重的调节，但遗传和环境影响对瘦素水平个体间变异的相对作用尚不清楚。设计和受试者：为探讨遗传和环境因素对体重指数（BMI）与血清瘦素水平之间关系的影响，（MZ，27 M，31 F）和74个性别相似的双合子（DZ，32男，42女）年龄在50 - 76岁的芬兰双胞胎对进行了研究。测量：血清瘦素水平，体重，身高，臀部和腰部测量。女性的平均瘦素水平（16.8 +/- 9.5 ng/ml）高于男性（6.4 +/- 3.5 ng/ml; P < 0.0001），瘦素水平的总体变异性也高于男性。瘦素水平与男性和女性的BMI高度相关。在女性中，瘦素的MZ和DZ配对相关性分别为0.41（P = 0.009）和0.07（P = 0.32）。在男性中，瘦素的MZ和DZ配对相关性分别为0.47（P = 0.006）和0.23（P = 0.10）。单变量双胞胎分析表明，在女性中，34%和男性中，45%的瘦素变异可归因于加性遗传效应，其余的独特的环境效应。无法证明显著的非加性遗传或共享家族效应。双变量双生子分析显示，瘦素与BMI的加性遗传效应相关系数在女性为0.79（95% CI 0.68 ~ 0.86），男性为0.68（95% CI 0.51 ~ 0.80）。环境对瘦素和BMI的影响之间的相关性为0.77（95%CI 0.66 - 0.85），在女性和0.48（0.26 - 0.66）在meson.CONCLUSION：瘦素水平是中度遗传的老年人，和相当大比例的遗传效应是共同的瘦素水平和肥胖的女性和男性。
OBJECTIVES: Leptin is involved in the regulation of body weight, but the relative role of genetic and environmental influences on inter-individual variation in leptin levels is unknown.DESIGN AND SUBJECTS: To investigate the genetic and environmental contributions to the association of body mass index (BMI) with serum leptin levels, 58 monozygotic (MZ, 27M, 31F), and 74 like-sexed dizygotic (DZ, 32M, 42F) Finnish twin pairs aged 50 - 76 y were studied.MEASUREMENTS: Serum leptin levels, weight, height, hip and waist measurements.RESULTS: Women had higher mean leptin levels (16.8 +/- 9.5 ng/ml), and more overall variability in leptin levels than men (6.4 +/- 3.5 ng/ml; P < 0.0001). Leptin levels correlated highly with BMI in men and women. Among women, the MZ and DZ pairwise correlations for leptin were 0.41 (P = 0.009) and 0.07 (P = 0.32), respectively. Among men the MZ and DZ pairwise correlations for leptin were 0.47 (P = 0.006) and 0.23 (P = 0.10). Univariate twin analysis indicated that, among women, 34% and, among men, 45% of the variance in leptin can be attributed to additive genetic effects, and the remainder to unique environmental effects. Significant non-additive genetic or shared familial effects could not be demonstrated. A bivariate twin analysis of leptin and BMI indicated that the correlation between additive genetic effects on leptin and BMI was 0.79 (95% CI 0.68 - 0.86) in women, and 0.68 (0.51 - 0.80) in men. The correlation between environmental effects on leptin and BMI was 0.77 (95% CI 0.66 - 0.85) in women, and 0.48 (0.26 - 0.66) in men.CONCLUSION: Leptin levels are moderately heritable in older adults, and a substantial proportion of genetic effects are in common on leptin levels and obesity in both women and men.