SOMATIC SENSORY CORTEX (SML) OF THE PROSIMIAN PRIMATE GALAGO-CRASSICAUDATUS - ORGANIZATION OF MECHANORECEPTIVE INPUT FROM THE HAND IN RELATION TO CYTOARCHITECTURE
SOMATIC SENSORY CORTEX (SML) OF THE PROSIMIAN PRIMATE GALAGO-CRASSICAUDATUS - ORGANIZATION OF MECHANORECEPTIVE INPUT FROM THE HAND IN RELATION TO CYTOARCHITECTURE
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DOI：
10.1002/cne.901890204
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发表时间：
1980-01-01
影响因子：
2.5
通讯作者：
WELT, C
中科院分区：
文献类型：
--
作者：
CARLSON, M;WELT, C
用微电极标记法研究了粗尾原猴从手到躯体感觉皮质(SMI)的机械感受传入。在麻醉动物中，手部的低阈值皮肤输入以单一的、完整的、有组织的躯体组织模式投射到SMI皮质。在这个单一的模式中，手掌无毛皮肤、指尖和指尖上具有感受野的细胞位于吻侧半部，而在手背毛皮和指端具有接受野的细胞位于手背区域的尾侧半部。手部皮肤区域与SMI致密颗粒状构造区同延。对清醒的Galagos这一区域的单个细胞的研究揭示了相同的皮肤输入模式，此外，还证明了在麻醉动物中没有检测到对关节运动做出反应的细胞的存在。响应关节运动的细胞排列在垂直定向的柱中，位于邻近皮肤柱的位置，在手的同一部分具有感受野。在麻醉动物中，颗粒区顶部的细胞对手部大片区域的高阈值刺激做出反应，该区域的典型特征是V层锥体细胞数量增加，上层颗粒细胞数量减少。在清醒的动物体内，分离在这一区域的少数细胞对主动或被动的手部运动做出反应。在这类动物中，颗粒区域尾部的细胞对单个或多个关节的被动刺激或主动的手运动做出反应，该区域以无颗粒和薄层皮质为特征。这些结果，以及相关的原猴Nycticebus Coucang的类似发现，强调了原猴种SMI中单一的手性皮肤尿素的共性。新旧大陆猿类SMI的多个手部区域对应于多个细胞构筑分区，说明了SMI从原猴到猿类组织分化的程度增加。要确定灵长类动物SMI内和周围多个区域或亚区的同源性，需要比较原猴和猿科代表性成员的体型、亚形态、沟模式、细胞结构和连通性。
Mechanoreceptive input from the hand to the somatic sensory cortex (SmI) of the prosimian primate G. crassicaudatus was examined with microelectrode mapping methods. In anesthetized animals, low threshold cutaneous input from the hand projects to SmI cortex in a single, complete, somatotopically organized pattern. Within this single pattern, cells with receptive fields [RF] on the glabrous skin of the palm, digits and digit tips are located in the rostral half, and cells with RE on the hair skin of the dorsal hand and digits are located in the caudal half of the hand area. The cutaneous hand area is coextensive with the densely granular architectonic region of SmI. Studies of single cells in this region of awake galagos reveal the same pattern of cutaneous input and, in addition, demonstrate the presence of cells responding to joint movement not detected in anesthetized animals. Cells responsive to joint movement are arranged in vertically oriented columns located adjacent to cutaneous columns with receptive fields on the same part of the hand. In anesthetized animals, cells rostral to the granular region, in an area typified by increasing numbers of pyramidal cells in layer V and decreasing numbers of granular cells in upper layers, respond to high threshold stimulation of large areas of the hand. The few cells isolated in this area in awake animals respond to either active or passive hand movements. In such animals, cells caudal to the granular region, in an area characterized as agranular and alaminar cortex, respond to either passive stimulatioon of single or multiple joints or to active hand movements. These results, together with similar findings in a related prosimian, Nycticebus coucang, emphasize the generality of a single cutaneous hand urea in SmI of prosimian species. The demonstration of multiple hand areas corresponding to multiple cytoarchitectonic subdivisions in SmI of Old and New World simians illustrates the increased degree of SmI differentiation from the prosimian to the simian grade of organizatioin. Determination of the homologues of multiple areas or subdivisions within and surrounding SmI in primates should require comparisons of somatotopy, submodality, sulcal patterns, cytoarchitecture and connectivity in representative members of prosimian and simian families.