The impact of diabetes on cognition: What can be learned from rodent models?
The impact of diabetes on cognition: What can be learned from rodent models?
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DOI：
10.1016/j.neurobiolaging.2005.08.015
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发表时间：
2005-12-01
影响因子：
4.2
通讯作者：
Gispen, WH
中科院分区：
文献类型：
--
作者：
Biessels, GJ;Gispen, WH
糖尿病与认知能力的轻度损伤有关，尤其是在老年人中。此外，患痴呆症的风险也会增加。我们在此回顾啮齿动物模型的研究，这些研究可能有助于确定糖尿病对大脑的这些不利影响的机制。学习和记忆、突触可塑性和谷氨酸能神经传递的异常现在已经在许多这些模型中被确定。总的来说，以慢性高血糖和低胰岛素血症为特征的模型（称为1型糖尿病模型）的观察结果是相当一致的，这些模型越来越多地用于研究发病机制和开发新的治疗方法。然而，以胰岛素抵抗、高胰岛素血症和中度高血糖（称为2型糖尿病模型）为特征的模型的结果则更加多变。此外，糖尿病和衰老之间可能的相互作用还没有得到足够详细的研究。由于临床上相关的认知缺陷主要发生在老年2型糖尿病患者中，因此进一步开发合适的模型将是该领域研究人员面临的挑战。(c) 2005爱思唯尔公司版权所有。
Diabetes mellitus is associated with modest impairments in cognition, particularly in the elderly. In addition, the risk of dementia is increased. We review herein studies in rodent models that may help to identify the mechanisms that underlie these adverse effects of diabetes on the brain. Abnormalities in learning and memory, synaptic plasticity, and glutamatergic neurotransmission have now been identified in a number of these models. In general, observations in models characterized by chronic hyperglycaemia and hypoinsulinaemia (referred to as models of type 1 diabetes) are quite consistent, and these models are being increasingly used to study the pathogenesis and to develop new treatments. However, results from models characterized by insulin resistance, hyperinsulinaemia, and modest hyperglycaemia (referred to as models of type 2 diabetes) are much more variable. Moreover, the possible interaction between diabetes and aging has not been examined in sufficient detail. Because clinically relevant cognitive deficits mainly occur in elderly patients with type 2 diabetes, the challenge for researchers in this field will be to further develop adequate models. (c) 2005 Elsevier Inc. All rights reserved.