AGE-SPECIFIC PREVALENCE OF PLASMODIUM-FALCIPARUM AMONG 6 POPULATIONS WITH LIMITED HISTORIES OF EXPOSURE TO ENDEMIC MALARIA
AGE-SPECIFIC PREVALENCE OF PLASMODIUM-FALCIPARUM AMONG 6 POPULATIONS WITH LIMITED HISTORIES OF EXPOSURE TO ENDEMIC MALARIA
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DOI：
10.4269/ajtmh.1993.49.707
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发表时间：
1993-12-01
影响因子：
3.3
通讯作者：
ARBANI, PR
中科院分区：
文献类型：
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作者：
BAIRD, JK;PURNOMO;ARBANI, PR
对印度尼西亚伊里安查亚东北部六个村庄的居民进行了为期五年的恶性疟原虫特定年龄流行率的测量。所有研究对象都是来自爪哇的移民，在Irian Jaya居住了三周到72个月，具体取决于村庄和测量点。从6个村庄的91至701人(平均样本量=304)的4554张Giemsa染色的厚血片中获得了15个不同的患病率估计。在Irian Jaya居住不到一年的人中，寄生虫血症的流行率并没有随着年龄的增长而下降，除了一个8个月大的村庄。相反，在居住16个月至两年或更长时间后，寄生虫血症的患病率随着年龄的增长而显著下降，超过6-10岁或11-15岁。这些人群的社会、行为或昆虫学特征不能解释寄生虫血症随着年龄的增长而下降的原因。在接触高流行疟疾1-2年后，所有这些村庄似乎都形成了依赖年龄的自然获得性保护性免疫。
The age-specific prevalence of Plasmodium falciparum parasitemia among residents of six villages in northeastern Irian Jaya, Indonesia, has been measured for a period of five years. All study subjects were transmigrants from Java living in Irian Jaya for three weeks to 72 months, depending upon the village and point of measurement. Fifteen separate estimates of prevalence were obtained from 4,554 Giemsa-stained thick blood films from 91 to 701 people (mean sample size = 304) among the six villages. The prevalence of parasitemia among people who had lived in Irian Jaya for less than one year did not decrease as a function of age, except in one village at eight months. In contrast, after 16 months to two years or more of residence, the prevalence of parasitemia decreased markedly with increasing age beyond 6-10 or 11-15 years. Social, behavioral, or entomologic characteristics of these populations did not explain the decreasing prevalence of parasitemia with age. An age-dependent naturally acquired protective immunity appeared to develop in all of these villages after 1-2 years of exposure to hyperendemic malaria.