A rapid and efficient synthesis of 2‐deoxy‐2‐[18F]fluoroacetamido‐D‐mannopyranose and ‐D‐galactopyranose
A rapid and efficient synthesis of 2‐deoxy‐2‐[18F]fluoroacetamido‐D‐mannopyranose and ‐D‐galactopyranose
复制标题
快速高效合成2-脱氧-2-[18F]氟乙酰氨基-D-吡喃甘露糖和-D-吡喃半乳糖
DOI：
10.1002/jlcr.2580280715
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发表时间：
1990
期刊：
影响因子：
--
通讯作者：
T. Ido
中科院分区：
文献类型：
--
作者：
M. Tada;A. Oikawa;R. Iwata;Kazunori Sato;K. Kubota;T. Fujiwara;H. Sugiyama;Y. Abe;Tachio Sato;T. Matsuzawa;H. Takahashi;A. Wakui;T. Ido
以[18F]氟化物和溴乙酸乙酯为原料，分别快速有效地合成了2-脱氧-2-[18F]氟乙酰氨基-D-吡喃甘露糖（1）和-D-吡喃半乳糖（2）。[18 F]氟化物是使用回旋加速器通过18 O（p，n）18 F核反应产生的。合成（1）和（2）所需的总时间约为10分钟。放化产率为18%，纯度≥ 98%。化合物（2）也以相同的放射化学产率和纯度合成。
Rapid and efficient syntheses of 2-deoxy-2-[18F]fluoroacetamido-D-mannopyranose (1) and -D-galactopyranose (2), respectively, starting from [18F]fluoride and ethyl bromoacetate are described. [18F]Fluoride was produced by the 18O (p, n) 18F nuclear reaction using the cyclotron. The total times required for synthesis of (1) and (2) are ca. 80 min. The radiochemical yield and purity of (1) are an 18% and ≥98%, respectively. Compound (2) is also synthesized with the same radiochemical yield and purity.