High capacity substrates as a platform for a DNA probe array genotyping assay
High capacity substrates as a platform for a DNA probe array genotyping assay
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DOI：
10.1081/ncn-100002329
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发表时间：
2001-01-01
影响因子：
1.3
通讯作者：
Frank, C
中科院分区：
文献类型：
--
作者：
Fidanza, J;Glazer, M;Frank, C
Colloidal silica particles were deposited on a glass substrate to produce high-capacity porous supports for high-density DNA probe arrays. Porous surfaces were used to increase the addressable surface area and number of probes available for hybridization. Surfaces derived from 70-100 nm size particles deposited in films from 0.15 to 2 microns thick exhibited excellent performance in light-directed oligonucleotide synthesis. Evaluation of these substrates in a genotyping assay is reported.
